HitPredict

Interactor 1: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: ELF3 (P78545)
ETS-related transcription factor Elf-3 (E74-like factor 3) (Epithelial-restricted with serine box) (Epithelium-restricted Ets protein ESX) (Epithelium-specific Ets transcription factor 1) (ESE-1)
Gene: ELF3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

The method score is based on:

Property	Details
Experiments	23687337, 11036073
Identification Methods	affinity chromatography technology, pull down, electrophoretic mobility supershift assay
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	Ank_2~Ets, Ank_2~SAM_PNT, Ets~RHD_dimer
Common GO terms	GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific GO:0003700 - DNA-binding transcription factor activity and 7 others more... GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0006357 - regulation of transcription by RNA polymerase II GO:0006954 - inflammatory response GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0060056 - mammary gland involution
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	968
Hs

1	371

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024