HitPredict

Interactor 1: NFKB1 (P19838)
Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]
Gene: NFKB1

Interactor 2: SLF1 (Q9BQI6)
SMC5-SMC6 complex localization factor protein 1 (Ankyrin repeat domain-containing protein 32) (BRCT domain-containing protein 1) (Smc5/6 localization factor 1)
Gene: SLF1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	35140242, 25609649
Identification Methods	proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~RHD_dimer
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 968 Hs			1 1058
+	Hs
		587690 NFKB1_HUMAN (1-968): 0: 796: 100.00		BARD1_HUMAN (790-935): 4.49e-42: 167: 41.22
+	Hs
		587628 NFKB1_HUMAN (1-968): 0: 796: 100.00		ANKH1_HUMAN (524-728): 1.74e-12: 74.3: 12.39
+	Hs
		276140 NFKB1_HUMAN (1-968): 0: 796: 100.00		PSD10_HUMAN (708-882): 3.85e-10: 63.2: 18.44
+	Mm
		103591 ANK3_MOUSE (381-967): 1e-99: 346: 14.24		ANK3_MOUSE (587-1057): 2.14e-96: 338: 15.24
+	Mm
		103608 ANK3_MOUSE (381-967): 1e-99: 346: 14.24		ANK2_MOUSE (740-1057): 4.36e-72: 265: 18.01
+	Hs
		167036 ANR50_HUMAN (360-930): 1.1e-108: 369: 13.96		ANR28_HUMAN (621-931): 5.04e-58: 219: 15.52
+	Hs
		978869 TF65_HUMAN (28-420): 6.77e-116: 368: 34.41		BARD1_HUMAN (790-935): 4.49e-42: 167: 41.22
+	Hs
		166913 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		ANR28_HUMAN (621-931): 5.04e-58: 219: 15.52
+	Hs
		883487 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		RIPK4_HUMAN (775-1057): 6.22e-51: 196: 17.12
+	Hs
		276172 TF65_HUMAN (28-420): 6.77e-116: 368: 34.41		PSD10_HUMAN (708-882): 3.85e-10: 63.2: 18.44
+	Dm
		957332 DIF_DROME (16-455): 1.18e-114: 368: 26.70		NFKB1_DROME (804-897): 8.47e-09: 62: 38.14
+	Hs
		166869 ANR28_HUMAN (650-967): 1.41e-49: 192: 14.82		TNKS1_HUMAN (742-1057): 1.26e-62: 235: 16.17
+	Hs
		883460 RIPK4_HUMAN (478-862): 1.18e-61: 227: 21.00		RIPK4_HUMAN (775-1057): 6.22e-51: 196: 17.12
+	Dm
		547633 DORS_DROME (42-387): 7.53e-107: 356: 37.96		NFKB1_DROME (804-897): 8.47e-09: 62: 38.14
+	Hs
		965154 ANK2_HUMAN (63-670): 1.17e-72: 266: 12.37		Q9H4D1_HUMAN (658-910): 4.06e-37: 152: 17.79
+	Hs
		166849 ANR28_HUMAN (650-967): 1.41e-49: 192: 14.82		ANR28_HUMAN (621-931): 5.04e-58: 219: 15.52
+	Hs
		883496 RIPK4_HUMAN (478-862): 1.18e-61: 227: 21.00		ANK3_HUMAN (624-860): 1.05e-44: 179: 12.24
+	Hs
		639798 IKBA_HUMAN (485-767): 1.18e-66: 228: 35.45		BARD1_HUMAN (790-935): 4.49e-42: 167: 41.22