HitPredict

Interactor 1: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Interactor 2: CXCR2 (P25025)
C-X-C chemokine receptor type 2 (CXC-R2) (CXCR-2) (CDw128b) (GRO/MGSA receptor) (High affinity interleukin-8 receptor B) (IL-8R B) (IL-8 receptor type 2) (CD antigen CD182)
Gene: CXCR2

Species: Homo sapiens

Source: dip

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	8702798
Identification Methods	biochemical
Interaction Type	physical association

Property	Details
Interacting Pfam domains	7tm_1~IL8
Common GO terms	GO:0006935 - chemotaxis GO:0006954 - inflammatory response GO:0030593 - neutrophil chemotaxis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 360
+	Hs
		587786 CXCL3_HUMAN (1-107): 9.63e-32: 109: 87.85		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		448988 GROA_HUMAN (1-107): 2.31e-31: 108: 89.72		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		364042 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		500672 CXCL2_MOUSE (9-107): 2.87e-32: 110: 62.63		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		625748 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		486185 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Hs
		625758 CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00		CXCR2_HUMAN (1-360): 2.21e-83: 259: 100.00
+	Mm
		522397 GROA_MOUSE (33-103): 4.04e-27: 97: 71.83		CXCR2_MOUSE (1-348): 2e-78: 246: 70.69
+	Hs
		364107 CXL10_HUMAN (17-102): 3e-22: 84.7: 27.27		CCR3_HUMAN (50-358): 1.44e-79: 249: 33.65
+	Hs
		364105 CXL10_HUMAN (17-102): 3e-22: 84.7: 27.27		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		217751 CXL13_HUMAN (38-107): 6.75e-22: 84.3: 25.35		CXCR3_HUMAN (21-357): 3.8e-79: 248: 40.71
+	Hs
		448987 GROA_HUMAN (1-107): 2.31e-31: 108: 89.72		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		364041 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625736 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		486184 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Hs
		625737 CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00		CXCR1_HUMAN (18-349): 2.54e-69: 222: 78.92
+	Mm
		291525 CXCL9_MOUSE (17-99): 3.45e-25: 93.2: 37.65		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67
+	Hs
		217747 CXL13_HUMAN (38-107): 6.75e-22: 84.3: 25.35		CXCR5_HUMAN (3-360): 2.25e-65: 213: 35.42
+	Hs
		217753 CXL13_HUMAN (38-107): 6.75e-22: 84.3: 25.35		ACKR4_HUMAN (4-358): 2.16e-65: 212: 31.55
+	Mm
		291524 CXL10_MOUSE (17-103): 5.91e-24: 89.3: 26.97		CXCR3_MOUSE (21-325): 9.97e-63: 206: 42.67