HitPredict

Interactor 1: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Interactor 2: MMP12 (P39900)
Macrophage metalloelastase (MME) (EC 3.4.24.65) (Macrophage elastase) (ME) (hME) (Matrix metalloproteinase-12) (MMP-12)
Gene: MMP12

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	18660381
Identification Methods	protease assay
Interaction Type	protein cleavage

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005615 - extracellular space
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 107 Hs			1 470
+	Hs
		587787 CXCL3_HUMAN (1-107): 9.63e-32: 109: 87.85		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		448989 GROA_HUMAN (1-107): 2.31e-31: 108: 89.72		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		364043 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		764724 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		486188 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		MMP12_HUMAN (1-470): 0: 665: 100.00
+	Hs
		486190 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		MMP13_HUMAN (1-470): 0: 639: 45.80
+	Hs
		372731 CXCL2_HUMAN (1-107): 5.5e-34: 114: 100.00		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		364034 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		372733 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		500671 CXCL2_MOUSE (9-107): 2.87e-32: 110: 62.63		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		372724 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Mm
		714631 CXCL3_MOUSE (9-107): 5.11e-31: 107: 58.59		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		372737 CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00		MMP1_HUMAN (11-470): 0: 608: 49.24
+	Hs
		612139 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		MMP8_HUMAN (13-470): 0: 599: 47.16
+	Hs
		486182 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		MMP8_HUMAN (13-470): 0: 599: 47.16
+	Mm
		522396 GROA_MOUSE (33-103): 4.04e-27: 97: 71.83		MMP12_MOUSE (1-470): 0: 593: 61.78
+	Hs
		540414 CXCL2_HUMAN (1-107): 5.5e-34: 114: 100.00		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		364037 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		540419 CXCL5_HUMAN (29-104): 3.05e-26: 95.5: 46.05		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77
+	Hs
		486175 IL8_HUMAN (25-107): 4.56e-25: 92: 40.00		MMP9_HUMAN (12-206): 2.35e-72: 243: 36.77