HitPredict

Interactor 1: CXCL2 (P19875)
C-X-C motif chemokine 2 (Growth-regulated protein beta) (Gro-beta) (Macrophage inflammatory protein 2-alpha) (MIP2-alpha) [Cleaved into: GRO-beta(5-73) (GRO-beta-T) (Hematopoietic synergistic factor) (HSF) (SB-251353)]
Gene: CXCL2

Interactor 2: SDF1 (P48061)
Stromal cell-derived factor 1 (SDF-1) (hSDF-1) (C-X-C motif chemokine 12) (Intercrine reduced in hepatomas) (IRH) (hIRH) (Pre-B cell growth-stimulating factor) (PBSF) [Cleaved into: SDF-1-beta(3-72); SDF-1-alpha(3-67)]
Gene: CXCL12

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.51	1.00	0.716

Property	Details
Experiments	28381538
Identification Methods	pull down, surface plasmon resonance, filter binding
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	IL8~IL8
Common GO terms	GO:0005576 - extracellular region GO:0006935 - chemotaxis GO:0008009 - chemokine activity GO:0045236 - CXCR chemokine receptor binding GO:0070098 - chemokine-mediated signaling pathway
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 107 Hs			1 93
+	Hs
		364045 CXCL7_HUMAN (25-106): 1.12e-27: 99.7: 48.78		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		816312 CXCL6_HUMAN (30-104): 1.15e-24: 91.6: 40.00		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		364104 CXL10_HUMAN (17-102): 3e-22: 84.7: 27.27		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		364079 PLF4_HUMAN (40-103): 4.61e-21: 82: 43.75		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		150316 CXL11_HUMAN (21-103): 8.75e-21: 80.9: 28.24		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		816314 CXCL9_HUMAN (33-99): 2.9e-20: 80.5: 47.06		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00
+	Hs
		499206 PF4V_HUMAN (40-103): 5.46e-19: 76.6: 40.63		SDF1_HUMAN (1-93): 4.72e-52: 159: 100.00