HitPredict

Interactor 1: DPA1 (P20036)
HLA class II histocompatibility antigen, DP alpha 1 chain (DP(W3)) (DP(W4)) (HLA-SB alpha chain) (MHC class II DP3-alpha) (MHC class II DPA1)
Gene: HLA-DPA1

Interactor 2: NR3L1 (Q68D85)
Natural cytotoxicity triggering receptor 3 ligand 1 (B7 homolog 6) (B7-H6)
Gene: NCR3LG1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	26186194, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C1-set~C1-set, C1-set~MHC_II_alpha
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 260 Hs			1 454
+	Hs
		588783 DPA1_HUMAN (1-260): 1.73e-90: 270: 100.00		BT2A1_HUMAN (19-324): 1.78e-34: 137: 14.79
+	Hs
		182246 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		TPSN_HUMAN (19-293): 2.7e-33: 132: 18.40
+	Hs
		382512 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		TPSNR_HUMAN (2-275): 1.18e-32: 130: 21.43
+	Mm
		537333 HA2B_MOUSE (7-260): 4e-90: 268: 58.98		TPSN_MOUSE (29-256): 2.75e-31: 126: 17.93
+	Hs
		182243 DQA1_HUMAN (7-260): 1.74e-87: 261: 57.65		TPSN_HUMAN (19-293): 2.7e-33: 132: 18.40
+	Hs
		382302 DPA1_HUMAN (1-260): 1.73e-90: 270: 100.00		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Mm
		354643 HA11_MOUSE (4-257): 5.57e-86: 261: 19.17		TPSN_MOUSE (29-256): 2.75e-31: 126: 17.93
+	Hs
		69945 B1PKZ2_HUMAN (4-258): 3.11e-84: 257: 18.35		TPSNR_HUMAN (2-275): 1.18e-32: 130: 21.43
+	Hs
		382258 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		354804 DQA1_HUMAN (7-260): 1.74e-87: 261: 57.65		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		382467 Q860B5_HUMAN (4-252): 3.38e-85: 258: 19.16		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		182247 DPB1_HUMAN (6-254): 2.52e-81: 246: 22.35		TPSN_HUMAN (19-293): 2.7e-33: 132: 18.40
+	Hs
		92644 E9PMV2_HUMAN (21-219): 6.31e-83: 248: 54.50		HLAA_HUMAN (113-296): 5.54e-30: 121: 20.86
+	Hs
		355014 DPA1_HUMAN (1-260): 1.73e-90: 270: 100.00		DQB1_HUMAN (121-243): 1.6e-22: 98.4: 21.14
+	Hs
		382554 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		BTNL2_HUMAN (32-275): 1.61e-22: 101: 16.67
+	Hs
		355008 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		DQB1_HUMAN (121-243): 1.6e-22: 98.4: 21.14
+	Hs
		354802 DQA1_HUMAN (7-260): 1.74e-87: 261: 57.65		DQB1_HUMAN (121-243): 1.6e-22: 98.4: 21.14
+	Hs
		354676 DRA_HUMAN (7-260): 8.11e-81: 244: 58.66		DMB_HUMAN (122-298): 6.25e-23: 99.5: 23.60
+	Hs
		354653 DRA_HUMAN (7-260): 8.11e-81: 244: 58.66		DQB1_HUMAN (121-243): 1.6e-22: 98.4: 21.14
+	Hs
		382421 HLAA_HUMAN (4-258): 2.01e-87: 265: 19.10		OPCM_HUMAN (150-368): 5.44e-11: 65.9: 10.96