HitPredict

Interactor 1: PRP4 (P20053)
U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4)
Gene: PRP4

Interactor 2: SN114 (P36048)
Pre-mRNA-splicing factor SNU114 (114 kDa U5 small nuclear ribonucleoprotein component) (Growth inhibitory protein 10)
Gene: SNU114

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	1.00	0.855

Property	Details
Experiments	11805826, 16429126, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	EFTUD2~WD40
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Sc			1 1008
+	Hs
		903237 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		U5S1_HUMAN (2-1007): 0: 898: 31.43
+	Hs
		197023 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		U5S1_HUMAN (2-1007): 0: 898: 31.43
+	Hs
		531105 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		EF2_HUMAN (117-995): 0: 846: 25.30
+	Hs
		1064590 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		U5S1_HUMAN (2-1007): 0: 898: 31.43
+	Hs
		1064834 PRP19_HUMAN (141-465): 1.26e-22: 102: 24.92		U5S1_HUMAN (2-1007): 0: 898: 31.43
+	Sc
		687359 TAF5_YEAST (261-380): 1.14e-16: 84.7: 33.88		EF2_YEAST (118-995): 0: 801: 23.96