HitPredict

Interactor 1: PRP4 (P20053)
U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4)
Gene: PRP4

Interactor 2: LSM2 (P38203)
U6 snRNA-associated Sm-like protein LSm2 (Small nuclear ribonucleoprotein D homolog SNP3)
Gene: LSM2

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	16554755, 16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071001 - U4/U6 snRNP
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 465 Sc			1 95
+	Sc
		589082 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		SMD3_YEAST (2-88): 5.25e-29: 101: 17.24
+	Sc
		589079 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		LSM4_YEAST (1-83): 6.06e-25: 93.9: 27.17
+	Hs
		903627 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		LSM2_HUMAN (1-95): 4.64e-40: 129: 63.16
+	Hs
		197110 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM2_HUMAN (1-95): 4.64e-40: 129: 63.16
+	Hs
		903646 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		LSM4_HUMAN (1-95): 1.42e-35: 119: 29.90
+	Hs
		197113 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM4_HUMAN (1-95): 1.42e-35: 119: 29.90
+	Hs
		903093 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		SMD3_HUMAN (2-88): 1.96e-32: 111: 17.24
+	Hs
		196993 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		SMD3_HUMAN (2-88): 1.96e-32: 111: 17.24
+	Hs
		903091 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		SMD1_HUMAN (1-95): 1.45e-26: 95.8: 27.37
+	Hs
		903090 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29
+	Hs
		196988 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29
+	Hs
		1288404 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		LSM2_HUMAN (1-95): 4.64e-40: 129: 63.16
+	Hs
		1288409 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		LSM4_HUMAN (1-95): 1.42e-35: 119: 29.90
+	Hs
		912701 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		SMD3_HUMAN (2-88): 1.96e-32: 111: 17.24
+	Hs
		912352 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		SMD1_HUMAN (1-95): 1.45e-26: 95.8: 27.37
+	Hs
		911927 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29
+	Hs
		911996 PRP19_HUMAN (141-465): 1.26e-22: 102: 24.92		RUXF_HUMAN (3-71): 1.74e-21: 82: 34.29