HitPredict

Interactor 1: PRP4 (P20053)
U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4)
Gene: PRP4

Interactor 2: LSM4 (P40070)
U6 snRNA-associated Sm-like protein LSm4 (Like-SM protein 4)
Gene: LSM4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	16429126, 37968396
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0017070 - U6 snRNA binding GO:0046540 - U4/U6 x U5 tri-snRNP complex and 1 others more... GO:0071001 - U4/U6 snRNP
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 465 Sc			1 187
+	Sc
		589082 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		SMD3_YEAST (2-104): 1.92e-30: 108: 26.21
+	Hs
		903646 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		LSM4_HUMAN (1-98): 5.13e-45: 147: 38.78
+	Hs
		197113 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM4_HUMAN (1-98): 5.13e-45: 147: 38.78
+	Hs
		903093 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		SMD3_HUMAN (2-108): 1.35e-33: 117: 26.17
+	Hs
		196993 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		SMD3_HUMAN (2-108): 1.35e-33: 117: 26.17
+	Hs
		1288409 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		LSM4_HUMAN (1-98): 5.13e-45: 147: 38.78
+	Hs
		912701 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		SMD3_HUMAN (2-108): 1.35e-33: 117: 26.17