HitPredict

Interactor 1: PRP4 (P20053)
U4/U6 small nuclear ribonucleoprotein PRP4 (Pre-mRNA-processing protein 4)
Gene: PRP4

Interactor 2: LSM3 (P57743)
U6 snRNA-associated Sm-like protein LSm3 (SmX4 protein)
Gene: LSM3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.706

Property	Details
Experiments	10747033, 19740761, 37968396, 14759368, 16429126
Identification Methods	biochemical, affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000398 - mRNA splicing, via spliceosome GO:0005634 - nucleus GO:0005681 - spliceosomal complex GO:0046540 - U4/U6 x U5 tri-snRNP complex GO:0071001 - U4/U6 snRNP
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Sc			1 89
+	Sc
		589089 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		LSM7_YEAST (2-83): 1.07e-20: 80.6: 30.23
+	Sc
		589097 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		SMD2_YEAST (4-76): 1.35e-20: 80.2: 30.67
+	Sc
		589080 PRP4_YEAST (1-465): 7.32e-119: 357: 100.00		LSM5_YEAST (4-83): 2.79e-19: 76.4: 24.69
+	Hs
		538887 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Hs
		196997 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		RSMN_HUMAN (10-86): 1.36e-24: 93.7: 26.51
+	Hs
		196951 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Hs
		197104 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM7_HUMAN (2-85): 7.35e-25: 91: 30.59
+	Hs
		196990 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM3_HUMAN (1-81): 7.88e-25: 90.6: 40.23
+	Hs
		903645 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		LSM5_HUMAN (4-85): 3.22e-21: 81.4: 23.17
+	Hs
		903092 WDR5_HUMAN (69-334): 3.26e-56: 191: 15.94		SMD2_HUMAN (4-76): 1.47e-20: 80.2: 28.05
+	Hs
		196935 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM8_HUMAN (6-89): 7.16e-22: 82.9: 23.81
+	Hs
		197112 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM5_HUMAN (4-85): 3.22e-21: 81.4: 23.17
+	Hs
		196991 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		LSM6_HUMAN (2-81): 5.33e-21: 80.2: 28.75
+	Hs
		196992 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		SMD2_HUMAN (4-76): 1.47e-20: 80.2: 28.05
+	Hs
		196989 PRP4_HUMAN (263-465): 1.49e-51: 183: 23.22		RUXG_HUMAN (8-81): 2.24e-20: 78.7: 27.03
+	Hs
		927996 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		RSMN_HUMAN (10-86): 1.36e-24: 93.7: 26.51
+	Hs
		539097 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51
+	Hs
		912535 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		SMD2_HUMAN (4-76): 1.47e-20: 80.2: 28.05
+	Hs
		912091 SNR40_HUMAN (70-291): 4.15e-35: 135: 12.39		RUXG_HUMAN (8-81): 2.24e-20: 78.7: 27.03
+	Hs
		539186 PRP19_HUMAN (141-465): 1.26e-22: 102: 24.92		RSMB_HUMAN (10-86): 3.53e-24: 92.9: 26.51