HitPredict

Interactor 1: CD33 (P20138)
Myeloid cell surface antigen CD33 (Sialic acid-binding Ig-like lectin 3) (Siglec-3) (gp67) (CD antigen CD33)
Gene: CD33

Interactor 2: KSYK (P43405)
Tyrosine-protein kinase SYK (EC 2.7.10.2) (Spleen tyrosine kinase) (p72-Syk)
Gene: SYK

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	17947393, 12763134
Identification Methods	pull down, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 364 Hs			1 635
+	Hs
		589562 CD33_HUMAN (11-364): 6.09e-86: 265: 100.00		ZAP70_HUMAN (6-635): 0: 535: 53.57
+	Hs
		590606 CD22_HUMAN (10-254): 1.34e-18: 89.1: 16.73		KSYK_HUMAN (1-635): 0: 589: 100.00
+	Mm
		722897 CD22_MOUSE (4-254): 3.42e-18: 88: 15.02		KSYK_MOUSE (1-635): 0: 567: 92.13
+	Mm
		546293 CXAR_MOUSE (5-354): 2.14e-51: 177: 14.29		NTRK2_MOUSE (164-631): 6.74e-116: 366: 23.96
+	Hs
		508005 OPCM_HUMAN (1-329): 1.1e-51: 176: 13.18		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		665239 OPCM_HUMAN (1-329): 1.1e-51: 176: 13.18		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		665204 CXAR_HUMAN (4-354): 1.35e-50: 174: 14.80		EPHA2_HUMAN (242-629): 6.67e-111: 357: 28.83
+	Hs
		508012 NECT1_HUMAN (3-331): 2.05e-45: 164: 17.98		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		522764 CD33_HUMAN (11-364): 6.09e-86: 265: 100.00		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		507951 PGBM_HUMAN (4-359): 2.07e-28: 119: 12.86		FGFR1_HUMAN (179-635): 7.43e-116: 366: 26.24
+	Hs
		433317 CXAR_HUMAN (4-354): 1.35e-50: 174: 14.80		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		338270 CXAR_HUMAN (4-354): 1.35e-50: 174: 14.80		EGFR_HUMAN (375-619): 8.73e-57: 209: 43.15
+	Hs
		383813 OPCM_HUMAN (1-329): 1.1e-51: 176: 13.18		ERBB2_HUMAN (375-619): 1.47e-52: 197: 42.34
+	Hs
		789096 SLAF5_HUMAN (4-362): 3.5e-45: 160: 19.11		ABL2_HUMAN (4-193): 3.72e-56: 207: 19.54
+	Hs
		412004 MAG_HUMAN (23-364): 3.4e-24: 105: 11.21		FYN_HUMAN (4-201): 3.14e-69: 236: 22.03
+	Hs
		523211 TUTLB_HUMAN (12-358): 1.65e-19: 92.2: 11.05		SRC_HUMAN (4-371): 2.15e-70: 239: 15.46
+	Hs
		433507 TUTLB_HUMAN (12-358): 1.65e-19: 92.2: 11.05		YES_HUMAN (4-203): 1.25e-68: 234: 20.80
+	Hs
		789014 TUTLB_HUMAN (12-358): 1.65e-19: 92.2: 11.05		TEC_HUMAN (4-379): 4.35e-48: 180: 12.71
+	Dm
		337715 Q9W4T9_DROME (64-311): 4.1e-14: 75.7: 8.49		SRC64_DROME (9-203): 3.92e-53: 192: 23.08