Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: TF2AA (P52655)
Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]
Gene: GTF2A1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 12941701, 26186194, 28514442, 29111974, 7724559, 33961781, 17643375, 11509574, 9603936, 11278496, 7958900, 35271311, 2247058, 8006019
Identification Methods affinity chromatography technology, pull down, enzymatic study, biochemical, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains TBP~TFIIA
Common GO terms GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005669 - transcription factor TFIID complex
and 5 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 339
Hs

1 376
+ Hs
+ Mm
+ Hs
+ Dm
+ Hs
+ Mm
+ Ce
+ Dm
+ Mm
+ Sc

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024