HitPredict

Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: TF2B (Q00403)
Transcription initiation factor IIB (EC 2.3.1.48) (General transcription factor TFIIB) (S300-II)
Gene: GTF2B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.964

The method score is based on:

Property Details
Experiments 14963322, 9159119, 17994014, 10619841, 7671313, 9054408, 15207618, 8006019
Identification Methods x-ray crystallography, biochemical, pull down, anti bait coimmunoprecipitation
Interaction Type association, direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains TBP~TFIIB
Common GO terms GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005669 - transcription factor TFIID complex
GO:0006366 - transcription by RNA polymerase II
and 4 others

more...
Homologous interactions 13

Homologous interactions

Color coding for hit scores

1 339
Hs

1 316
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+ Sc
+ Hs
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+ Dm
+ At
+ Pf

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Last updated: 15 Jul 2024