HitPredict

Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: NC2B (Q01658)
Protein Dr1 (Down-regulator of transcription 1) (Negative cofactor 2-beta) (NC2-beta) (TATA-binding protein-associated phosphoprotein)
Gene: DR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.917

Property	Details
Experiments	25416956, 18838386, 32296183, 35271311, 31515488
Identification Methods	two hybrid, pull down, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CBFD_NFYB_HMF~TBP
Common GO terms	GO:0005654 - nucleoplasm GO:0016251 - RNA polymerase II general transcription initiation factor activity GO:0051123 - RNA polymerase II preinitiation complex assembly
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 339 Hs			1 176
+	Hs
		589781 TBP_HUMAN (1-339): 7.86e-144: 411: 100.00		NFYB_HUMAN (2-151): 4.15e-47: 154: 25.95
+	Hs
		1103930 Q32MN6_HUMAN (1-339): 5.1e-134: 384: 80.53		Q658N3_HUMAN (1-142): 1.03e-53: 170: 100.00
+	Hs
		966149 Q32MN6_HUMAN (1-339): 5.1e-134: 384: 80.53		NC2B_HUMAN (1-142): 1.03e-53: 170: 100.00
+	Sc
		527085 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		NCB2_YEAST (5-132): 2.37e-32: 114: 40.31