HitPredict

Interactor 1: TBP (P20226)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: NC2A (Q14919)
Dr1-associated corepressor (Dr1-associated protein 1) (Negative cofactor 2-alpha) (NC2-alpha)
Gene: DRAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

Property	Details
Experiments	18838386, 35271311, 11461703, 15574413
Identification Methods	pull down, affinity chromatography technology, x-ray crystallography, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	CBFD_NFYB_HMF~TBP
Common GO terms	GO:0001046 - core promoter sequence-specific DNA binding GO:0001091 - RNA polymerase II general transcription initiation factor binding GO:0005634 - nucleus GO:0006366 - transcription by RNA polymerase II GO:0016251 - RNA polymerase II general transcription initiation factor activity
Homologous interactions	2

Homologous interactions

Color coding for hit scores

	1 339 Hs			1 205
+	Hs
		589858 TBP_HUMAN (1-339): 7.86e-144: 411: 100.00		NFYC_HUMAN (3-101): 1.3e-37: 137: 28.28
+	Sc
		527008 TBP_YEAST (120-337): 9.51e-102: 301: 69.73		NCB1_YEAST (6-85): 3.39e-23: 92.2: 45.00