HitPredict

Interactor 1: TBP (P20227)
TATA-box-binding protein (TATA sequence-binding protein) (TATA-binding factor) (TATA-box factor) (Transcription initiation factor TFIID TBP subunit)
Gene: TBP

Interactor 2: TAF1 (P51123)
Transcription initiation factor TFIID subunit 1 (EC 2.7.11.1) (TAFII250) (TBP-associated factor 230 kDa) (p230) (Transcription initiation factor TFIID 230 kDa subunit) (TAFII-230)
Gene: TAF1

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.95 1.00 0.976

The method score is based on:

Property Details
Experiments 11438676, 7923382, 8170939, 8178153, 8276241, 25242320, 16415879, 17030624, rtd:8464492, 8464492, unassigned4
Identification Methods affinity chromatography technology, biochemical, biophysical, experimental interaction detection, comigration in non denaturing gel electrophoresis, far western blotting, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains DUF3591~TBP, TBP~TBP-binding
Common GO terms GO:0005634 - nucleus
GO:0005669 - transcription factor TFIID complex
GO:0006367 - transcription initiation at RNA polymerase II promoter
GO:0016251 - RNA polymerase II general transcription initiation factor activity
GO:0051123 - RNA polymerase II preinitiation complex assembly
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 353
Dm

1 2129
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc
+ Sc
+ At
+ At
+ Sc

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Last updated: 15 Jul 2024