HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: CDK7 (P50613)
Cyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Gene: CDK7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	1.00	0.924

Property	Details
Experiments	26186194, 28514442, 33961781, 16327805, 11113184
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 346
+	Hs
		590125 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		590162 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	Hs
		414732 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		590164 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09
+	Hs
		625350 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Mm
		851183 CCNA2_MOUSE (4-432): 3.17e-135: 396: 85.12		CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54
+	Mm
		956329 CCNA1_MOUSE (10-432): 2.81e-130: 383: 46.15		CDK2_MOUSE (9-307): 1.16e-141: 406: 37.54
+	Mm
		509476 CCNA2_MOUSE (4-432): 3.17e-135: 396: 85.12		CDK1_MOUSE (9-298): 3.17e-133: 383: 43.35
+	Hs
		414855 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		538471 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK2_HUMAN (9-307): 2.6e-150: 426: 43.85
+	Hs
		538497 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK7_HUMAN (1-346): 2.36e-147: 420: 100.00
+	Hs
		538521 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK3_HUMAN (9-307): 7.94e-143: 407: 44.85
+	At
		1104377 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD1_ARATH (3-324): 3.66e-135: 392: 53.73
+	At
		1104376 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD2_ARATH (1-345): 4.32e-135: 389: 51.45
+	At
		621660 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKA1_ARATH (9-298): 7.86e-134: 384: 43.54
+	At
		1104379 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CDKD3_ARATH (1-342): 5.25e-132: 383: 51.75
+	At
		1104370 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKB21_ARATH (9-302): 2.14e-129: 374: 38.49
+	Hs
		414711 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK1_HUMAN (9-298): 6.62e-135: 387: 43.00
+	Hs
		538522 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CDK5_HUMAN (9-301): 1.39e-134: 386: 45.09
+	At
		1103349 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKB12_ARATH (9-298): 1.82e-128: 371: 41.10