HitPredict

Interactor 1: CCNA2 (P20248)
Cyclin-A2 (Cyclin-A) (Cyclin A)
Gene: CCNA2

Interactor 2: CKS1 (P61024)
Cyclin-dependent kinases regulatory subunit 1 (CKS-1)
Gene: CKS1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	28514442, 11907280, 33961781, 19483727, 26186194, 26496610, 33422522, 18471975
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005654 - nucleoplasm GO:0019901 - protein kinase binding GO:0044772 - mitotic cell cycle phase transition GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 432 Hs			1 79
+	Hs
		590135 CCNA2_HUMAN (1-432): 1.56e-151: 438: 100.00		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Hs
		895411 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		706795 CCNA1_HUMAN (15-432): 7.29e-131: 386: 46.46		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188148 CCA23_ARATH (4-430): 1.19e-116: 350: 31.76		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		538505 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	Hs
		538483 CCNB1_HUMAN (23-425): 1.93e-111: 336: 27.71		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	At
		188149 CCB12_ARATH (3-430): 2.87e-108: 328: 27.27		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1106919 CCB12_ARATH (3-430): 2.87e-108: 328: 27.27		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188167 CCB23_ARATH (8-430): 1.51e-106: 323: 26.18		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Hs
		303840 CCNB2_HUMAN (45-425): 1.39e-104: 317: 29.77		CKS1_HUMAN (1-79): 9.36e-40: 127: 100.00
+	At
		1324477 CCA31_ARATH (82-432): 1.61e-107: 323: 34.92		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188178 CCB24_ARATH (20-432): 9.9e-106: 321: 26.51		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	At
		1352139 CCB24_ARATH (20-432): 9.9e-106: 321: 26.51		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57
+	At
		188134 CCB14_ARATH (37-432): 3.42e-105: 318: 27.43		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Dm
		540500 CCNA_DROME (5-429): 1.67e-103: 317: 32.48		Q9VHN1_DROME (1-71): 6.77e-38: 123: 71.83
+	Hs
		303832 CCNB2_HUMAN (45-425): 1.39e-104: 317: 29.77		CKS2_HUMAN (1-79): 5.68e-38: 122: 81.01
+	Sc
		594112 CG24_YEAST (4-431): 5.18e-106: 323: 22.15		CKS1_YEAST (3-73): 3.34e-32: 110: 50.00
+	At
		48925 CCA33_ARATH (133-432): 1.04e-102: 310: 37.22		CKS1_ARATH (5-73): 1.35e-37: 122: 69.57
+	Dm
		540479 CCNA_DROME (5-429): 1.67e-103: 317: 32.48		CKS1_DROME (4-72): 4.45e-35: 115: 78.26
+	At
		48953 CCA33_ARATH (133-432): 1.04e-102: 310: 37.22		CKS2_ARATH (5-78): 3.45e-37: 120: 67.57