HitPredict

Interactor 1: TNR1B (P20333)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
Gene: TNFRSF1B

Interactor 2: ADA17 (P78536)
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) (EC 3.4.24.86) (Snake venom-like protease) (TNF-alpha convertase) (TNF-alpha-converting enzyme) (CD antigen CD156b)
Gene: ADAM17

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	36185580, 17010968
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0016020 - membrane GO:0043120 - tumor necrosis factor binding GO:0045121 - membrane raft
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 824
+	Hs
		584375 TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36		ADA17_HUMAN (1-824): 0: 881: 100.00
+	Hs
		632399 TNR6_HUMAN (44-320): 6.35e-39: 145: 15.77		ADAM7_HUMAN (45-627): 3.36e-112: 361: 19.74
+	Hs
		257274 FRAS1_HUMAN (35-259): 1.23e-10: 66.1: 13.23		ATS4_HUMAN (34-658): 5.34e-114: 368: 15.09
+	Hs
		1204967 FRAS1_HUMAN (35-259): 1.23e-10: 66.1: 13.23		ADA30_HUMAN (40-635): 1.29e-111: 360: 19.90