HitPredict

Interactor 1: TNR1B (P20333)
Tumor necrosis factor receptor superfamily member 1B (Tumor necrosis factor receptor 2) (TNF-R2) (Tumor necrosis factor receptor type II) (TNF-RII) (TNFR-II) (p75) (p80 TNF-alpha receptor) (CD antigen CD120b) (Etanercept) [Cleaved into: Tumor necrosis factor receptor superfamily member 1b, membrane form; Tumor necrosis factor-binding protein 2 (TBP-2) (TBPII)]
Gene: TNFRSF1B

Interactor 2: BIRC2 (Q13490)
Baculoviral IAP repeat-containing protein 2 (EC 2.3.2.27) (Cellular inhibitor of apoptosis 1) (C-IAP1) (IAP homolog B) (Inhibitor of apoptosis protein 2) (hIAP-2) (hIAP2) (RING finger protein 48) (RING-type E3 ubiquitin transferase BIRC2) (TNFR2-TRAF-signaling complex protein 2)
Gene: BIRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

Property	Details
Experiments	33961781, 9718306, 8548810
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0033209 - tumor necrosis factor-mediated signaling pathway
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 461 Hs			1 618
+	Hs
		738663 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		639581 TNR5_HUMAN (29-267): 7.76e-40: 146: 26.12		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Hs
		584398 TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Mm
		648960 TNR5_MOUSE (29-275): 3.58e-45: 160: 22.74		BIRC2_MOUSE (1-618): 0: 657: 82.74
+	Hs
		645799 CD27_HUMAN (37-134): 1.7e-19: 89.6: 28.00		BIRC2_HUMAN (1-618): 0: 702: 100.00
+	Mm
		626867 TNR1A_MOUSE (32-256): 4.92e-32: 129: 20.24		BIRC2_MOUSE (1-618): 0: 657: 82.74
+	Mm
		140020 TNR5_MOUSE (29-275): 3.58e-45: 160: 22.74		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	Mm
		140023 TNR3_MOUSE (24-261): 6.69e-36: 139: 26.15		BIRC3_MOUSE (21-618): 0: 624: 66.28
+	Hs
		591324 TNR1B_HUMAN (1-461): 5.19e-141: 413: 100.00		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		738662 TNR3_HUMAN (2-216): 5.3e-47: 169: 30.94		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		584397 TNR1A_HUMAN (32-256): 2.62e-36: 141: 22.36		BIRC3_HUMAN (5-259): 2.61e-52: 191: 28.03
+	Hs
		436615 TNR16_HUMAN (34-313): 6.31e-47: 169: 21.18		MDM2_HUMAN (344-617): 6.07e-34: 137: 15.56