HitPredict

Interactor 1: RAB4A (P20338)
Ras-related protein Rab-4A (EC 3.6.5.2)
Gene: RAB4A

Interactor 2: RUFY1 (Q96T51)
RUN and FYVE domain-containing protein 1 (FYVE-finger protein EIP1) (La-binding protein 1) (Rab4-interacting protein) (Zinc finger FYVE domain-containing protein 12)
Gene: RUFY1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.900

Property	Details
Experiments	14617813, 34079125, 37232246, 20534812
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology, two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	RUN~Ras
Common GO terms	GO:0015031 - protein transport GO:0030100 - regulation of endocytosis GO:0031901 - early endosome membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 218 Hs			1 708
+	Hs
		895236 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Hs
		896669 RAB14_HUMAN (3-217): 2.42e-84: 250: 57.21		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Hs
		914301 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		RUFY1_HUMAN (1-708): 9.63e-73: 251: 100.00
+	Dm
		1197049 Q86BK8_DROME (3-218): 6.99e-93: 273: 56.94		Q9W2M0_DROME (319-704): 5.75e-46: 175: 19.74
+	Hs
		592071 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		FYV1_HUMAN (545-708): 1.05e-38: 156: 25.56
+	Dm
		1182873 Q7KY04_DROME (6-216): 7.32e-92: 269: 77.25		Q8IMP0_DROME (105-560): 5.94e-35: 144: 40.00
+	Hs
		895143 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		RUFY3_HUMAN (109-527): 2.56e-32: 132: 56.33
+	Hs
		895123 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		895066 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96
+	Hs
		254463 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		ROCK2_HUMAN (348-660): 2.44e-10: 66.1: 12.81
+	Hs
		591838 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		ROCK1_HUMAN (102-638): 4.76e-13: 74.9: 12.96
+	Hs
		895105 RAB2A_HUMAN (10-197): 2.28e-93: 273: 56.92		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95
+	Hs
		591852 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		EEA1_HUMAN (326-667): 1.35e-11: 70.4: 11.92
+	Hs
		591955 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		RUFY2_HUMAN (99-467): 1.2e-11: 70: 10.84
+	Hs
		914124 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		MRCKA_HUMAN (386-662): 9.1e-15: 80.6: 13.27
+	Hs
		313502 RAB4A_HUMAN (1-218): 5.41e-88: 260: 100.00		ZFYV9_HUMAN (639-700): 4.53e-10: 65.5: 41.27
+	Hs
		914203 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		WDFY3_HUMAN (639-696): 1.25e-10: 67.4: 43.33
+	Hs
		254466 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		ROCK2_HUMAN (348-660): 2.44e-10: 66.1: 12.81
+	Hs
		313523 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		ZFYV9_HUMAN (639-700): 4.53e-10: 65.5: 41.27
+	Hs
		914103 RB11A_HUMAN (3-217): 8.33e-84: 249: 42.33		GRDN_HUMAN (312-647): 7.56e-09: 61.4: 16.95