HitPredict

Interactor 1: RAB5A (P20339)
Ras-related protein Rab-5A (EC 3.6.5.2)
Gene: RAB5A

Interactor 2: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, 34079125, unassigned2173
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0043231 - intracellular membrane-bounded organelle GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 215 Hs			1 2472
+	Hs
		914061 RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32		SPTN1_HUMAN (1-2472): 0: 714: 100.00
+	Hs
		164585 RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57		SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41
+	Mm
		1112496 RAB5A_MOUSE (1-215): 6.55e-89: 262: 98.14		Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60
+	Mm
		722701 RAB5C_MOUSE (1-215): 1.69e-85: 253: 86.57		Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60
+	Hs
		844487 RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		914014 RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32		SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52
+	Hs
		592257 RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		918867 RAB1A_HUMAN (11-213): 2.59e-87: 257: 41.18		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		592215 RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		844524 RAB5C_HUMAN (1-215): 3.96e-85: 252: 86.57		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		914077 RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32		GOGB1_HUMAN (2-1186): 3.65e-38: 160: 10.57
+	Hs
		914020 RB11A_HUMAN (11-215): 7.77e-83: 247: 38.32		DYST_HUMAN (5-2410): 1.41e-35: 152: 10.59
+	Hs
		592583 RAB5A_HUMAN (1-215): 2.09e-88: 260: 100.00		MACF1_HUMAN (9-1261): 9.1e-18: 93.6: 12.48
+	Mm
		899116 RAB6B_MOUSE (11-207): 3.76e-52: 168: 42.93		ACTN2_MOUSE (1843-2210): 5.15e-13: 77: 23.23