Interactor 1: TKN1 (P20366)
Protachykinin-1 (PPT) [Cleaved into: Substance P; Neurokinin A (NKA) (Neuromedin L) (Substance K); Neuropeptide K (NPK); Neuropeptide gamma; C-terminal-flanking peptide]
Gene: TAC1

Interactor 2: NK1R (P25103)
Substance-P receptor (SPR) (NK-1 receptor) (NK-1R) (Tachykinin receptor 1)
Gene: TACR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.70 1.00 0.840

The method score is based on:

Property Details
Experiments 11786503, 8702757, 23597562
Identification Methods pull down, scintillation proximity assay
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains 7tm_1~Tachykinin
Common GO terms GO:0006954 - inflammatory response
GO:0007204 - positive regulation of cytosolic calcium ion concentration
GO:0007217 - tachykinin receptor signaling pathway
GO:0009582 - detection of abiotic stimulus
Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 129
Hs

1 407
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024