HitPredict

Interactor 1: NR1D1 (P20393)
Nuclear receptor subfamily 1 group D member 1 (Rev-erbA-alpha) (V-erbA-related protein 1) (EAR-1)
Gene: NR1D1

Interactor 2: SPSB4 (Q96A44)
SPRY domain-containing SOCS box protein 4 (SSB-4)
Gene: SPSB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	31607207, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0042752 - regulation of circadian rhythm
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 614 Hs			1 273
+	Hs
		592822 NR1D1_HUMAN (1-614): 1.32e-145: 436: 100.00		SPSB2_HUMAN (1-273): 8.89e-98: 289: 50.92
+	Dm
		51265 FTZF1_DROME (64-610): 9.1e-87: 293: 19.54		GUS_DROME (1-273): 1.44e-123: 355: 68.23
+	Hs
		824229 NR2C2_HUMAN (20-613): 2.33e-106: 335: 18.59		DDX1_HUMAN (6-237): 1.72e-46: 167: 19.07
+	Hs
		824336 NR2C2_HUMAN (20-613): 2.33e-106: 335: 18.59		HNRL1_HUMAN (86-268): 5.21e-17: 82.6: 20.50
+	Mm
		509337 RARA_MOUSE (45-207): 3.55e-45: 168: 36.81		DDX1_MOUSE (6-237): 1.63e-47: 170: 19.49
+	Hs
		500501 THB_HUMAN (76-304): 5.85e-42: 159: 26.05		RANB9_HUMAN (55-273): 3.11e-46: 166: 14.85
+	Hs
		818879 RXRG_HUMAN (4-265): 1.86e-51: 186: 27.47		TRI67_HUMAN (52-232): 1.14e-36: 139: 19.37
+	Hs
		500445 THA_HUMAN (90-249): 6.37e-40: 154: 34.16		RANB9_HUMAN (55-273): 3.11e-46: 166: 14.85
+	Hs
		659723 RXRB_HUMAN (72-244): 2.01e-39: 153: 28.90		TRI67_HUMAN (52-232): 1.14e-36: 139: 19.37
+	Hs
		975469 PPARD_HUMAN (447-606): 3.09e-22: 101: 38.55		RANB9_HUMAN (55-273): 3.11e-46: 166: 14.85
+	Hs
		740590 PPARG_HUMAN (446-606): 2.3e-24: 108: 38.04		HNRL1_HUMAN (86-268): 5.21e-17: 82.6: 20.50