HitPredict

Interactor 1: CG12 (P20438)
G1/S-specific cyclin CLN2
Gene: CLN2

Interactor 2: CKS1 (P20486)
Cyclin-dependent kinases regulatory subunit (Cell division control protein CKS1)
Gene: CKS1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.733

Property	Details
Experiments	11805826, 15200949, 28496991, 20489023, 10913169, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division GO:1902806 - regulation of cell cycle G1/S phase transition
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 545 Sc			1 150
+	Sc
		593356 CG11_YEAST (6-541): 1.12e-151: 447: 56.12		CKS1_YEAST (1-150): 5.02e-67: 201: 100.00
+	Sc
		594110 CG22_YEAST (6-319): 3.55e-71: 237: 14.01		CKS1_YEAST (1-150): 5.02e-67: 201: 100.00
+	Hs
		303840 CCNB2_HUMAN (1-343): 6.9e-79: 254: 13.80		CKS1_HUMAN (27-104): 2.53e-31: 109: 51.28
+	Hs
		538505 CCNB1_HUMAN (2-322): 2.95e-77: 251: 12.81		CKS1_HUMAN (27-104): 2.53e-31: 109: 51.28
+	At
		48953 CCA33_ARATH (25-326): 6.84e-72: 234: 12.62		CKS2_ARATH (25-115): 3.02e-37: 124: 49.45
+	At
		1324477 CCA31_ARATH (2-326): 4.62e-71: 233: 11.55		CKS2_ARATH (25-115): 3.02e-37: 124: 49.45
+	At
		1106919 CCB12_ARATH (5-332): 8.71e-70: 232: 14.59		CKS2_ARATH (25-115): 3.02e-37: 124: 49.45
+	At
		1352139 CCB24_ARATH (17-293): 7.35e-69: 229: 13.31		CKS2_ARATH (25-115): 3.02e-37: 124: 49.45
+	At
		188167 CCB23_ARATH (1-266): 8.37e-71: 234: 14.18		CKS1_ARATH (25-104): 2.38e-35: 119: 48.75
+	Hs
		303832 CCNB2_HUMAN (1-343): 6.9e-79: 254: 13.80		CKS2_HUMAN (27-109): 1.16e-27: 99: 49.40
+	At
		48925 CCA33_ARATH (25-326): 6.84e-72: 234: 12.62		CKS1_ARATH (25-104): 2.38e-35: 119: 48.75
+	At
		188149 CCB12_ARATH (5-332): 8.71e-70: 232: 14.59		CKS1_ARATH (25-104): 2.38e-35: 119: 48.75
+	Hs
		538483 CCNB1_HUMAN (2-322): 2.95e-77: 251: 12.81		CKS2_HUMAN (27-109): 1.16e-27: 99: 49.40
+	At
		188178 CCB24_ARATH (17-293): 7.35e-69: 229: 13.31		CKS1_ARATH (25-104): 2.38e-35: 119: 48.75
+	Hs
		895411 CCNA1_HUMAN (11-299): 6.55e-70: 233: 15.23		CKS1_HUMAN (27-104): 2.53e-31: 109: 51.28
+	At
		188134 CCB14_ARATH (2-302): 8.64e-67: 222: 13.58		CKS1_ARATH (25-104): 2.38e-35: 119: 48.75
+	Hs
		590156 CCNA2_HUMAN (4-302): 3.84e-69: 230: 16.12		CKS1_HUMAN (27-104): 2.53e-31: 109: 51.28
+	Hs
		331636 CCNE2_HUMAN (41-391): 1.28e-66: 223: 13.98		CKS1_HUMAN (27-104): 2.53e-31: 109: 51.28
+	Hs
		706795 CCNA1_HUMAN (11-299): 6.55e-70: 233: 15.23		CKS2_HUMAN (27-109): 1.16e-27: 99: 49.40
+	Hs
		590135 CCNA2_HUMAN (4-302): 3.84e-69: 230: 16.12		CKS2_HUMAN (27-109): 1.16e-27: 99: 49.40