HitPredict

Interactor 1: MSH3 (P20585)
DNA mismatch repair protein Msh3 (hMSH3) (Divergent upstream protein) (DUP) (Mismatch repair protein 1) (MRP1)
Gene: MSH3

Interactor 2: RFA1 (P27694)
Replication protein A 70 kDa DNA-binding subunit (RP-A p70) (Replication factor A protein 1) (RF-A protein 1) (Single-stranded DNA-binding protein) [Cleaved into: Replication protein A 70 kDa DNA-binding subunit, N-terminally processed]
Gene: RPA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	26212458, 37827155, 24332808
Identification Methods	pull down, proximity labelling technology, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006298 - mismatch repair
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 1137 Hs			1 616
+	Hs
		650738 MSH6_HUMAN (81-1126): 0: 978: 22.85		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Hs
		650583 MSH2_HUMAN (239-1127): 0: 777: 23.81		RFA1_HUMAN (1-616): 0: 781: 100.00
+	Sc
		607331 MSH6_YEAST (109-1113): 0: 807: 23.68		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		607210 MSH3_YEAST (218-1110): 0: 705: 32.30		RFA1_YEAST (4-615): 0: 596: 31.69
+	Sc
		607214 MSH2_YEAST (234-1135): 0: 658: 23.19		RFA1_YEAST (4-615): 0: 596: 31.69