HitPredict

Interactor 1: PSB1 (P20618)
Proteasome subunit beta type-1 (Macropain subunit C5) (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5) (Proteasome gamma chain)
Gene: PSMB1

Interactor 2: PSME2 (Q9UL46)
Proteasome activator complex subunit 2 (11S regulator complex subunit beta) (REG-beta) (Activator of multicatalytic protease subunit 2) (Proteasome activator 28 subunit beta) (PA28b) (PA28beta)
Gene: PSME2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	35271311, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PA28_beta~Proteasome
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 241 Hs			1 239
+	Hs
		832056 PSB3_HUMAN (31-241): 3.45e-82: 246: 23.94		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		594500 PSB1_HUMAN (1-241): 8.65e-85: 253: 100.00		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		156373 PSA7_HUMAN (17-241): 8.16e-79: 238: 13.54		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		656084 PSB8_HUMAN (14-230): 1.02e-77: 237: 21.27		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		831970 PSB3_HUMAN (31-241): 3.45e-82: 246: 23.94		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		638215 PSA4_HUMAN (8-240): 1.49e-75: 231: 17.72		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		594513 PSB1_HUMAN (1-241): 8.65e-85: 253: 100.00		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		656335 PSA5_HUMAN (16-240): 7.6e-75: 228: 16.67		PSME2_HUMAN (1-239): 1.08e-111: 322: 100.00
+	Hs
		156268 PSA7_HUMAN (17-241): 8.16e-79: 238: 13.54		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		831980 PSB3_HUMAN (31-241): 3.45e-82: 246: 23.94		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		638103 PSA4_HUMAN (8-240): 1.49e-75: 231: 17.72		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		656192 PSA5_HUMAN (16-240): 7.6e-75: 228: 16.67		PSME3_HUMAN (7-239): 1.24e-106: 309: 33.60
+	Hs
		156276 PSA7_HUMAN (17-241): 8.16e-79: 238: 13.54		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		656058 PSB8_HUMAN (14-230): 1.02e-77: 237: 21.27		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Dm
		1358995 PSB3_DROME (31-241): 1.58e-80: 241: 24.41		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Hs
		893656 PSA6_HUMAN (17-240): 4.32e-77: 234: 14.91		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		638116 PSA4_HUMAN (8-240): 1.49e-75: 231: 17.72		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Hs
		656208 PSA5_HUMAN (16-240): 7.6e-75: 228: 16.67		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97
+	Dm
		1278635 PSA5_DROME (16-240): 5.24e-75: 229: 17.37		Q9V3P3_DROME (16-239): 1.47e-100: 293: 32.77
+	Hs
		656704 PSB5_HUMAN (9-230): 4.76e-73: 224: 20.27		PSME1_HUMAN (7-239): 3.47e-102: 298: 47.97