HitPredict

Interactor 1: NUP1 (P20676)
Nucleoporin NUP1 (Nuclear pore protein NUP1)
Gene: NUP1

Interactor 2: IMB3 (P32337)
Importin subunit beta-3 (Karyopherin subunit beta-3) (Karyopherin-121) (Protein secretion enhancer 1)
Gene: PSE1

Species: Saccharomyces cerevisiae S288C

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	10678175, 9368759, 25942622, 22357553
Identification Methods	affinity chromatography technology, two hybrid, fluorescent resonance energy transfer, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0006606 - protein import into nucleus GO:0008139 - nuclear localization sequence binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1076 Sc			1 1089
+	Sc
		595034 NUP1_YEAST (1-1076): 2e-160: 505: 100.00		IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75
+	Sc
		595023 NUP1_YEAST (1-1076): 2e-160: 505: 100.00		IMB2_YEAST (12-589): 3.14e-48: 188: 18.28
+	Sc
		687906 NUP2_YEAST (435-840): 1.31e-31: 135: 25.17		IMB3_YEAST (1-1089): 3.51e-179: 555: 100.00
+	Sc
		595074 NUP1_YEAST (1-1076): 2e-160: 505: 100.00		IMB1_YEAST (14-701): 1.06e-46: 183: 15.89
+	Sc
		687954 NU159_YEAST (347-936): 2.15e-17: 90.3: 14.33		IMB3_YEAST (1-1089): 3.51e-179: 555: 100.00
+	Sc
		541851 NSP1_YEAST (511-1032): 4.79e-13: 75.7: 16.10		IMB3_YEAST (1-1089): 3.51e-179: 555: 100.00
+	Hs
		834652 NU153_HUMAN (3-977): 5.82e-79: 285: 14.89		TNPO1_HUMAN (293-1089): 1.13e-68: 250: 11.87
+	Hs
		155550 NU153_HUMAN (3-977): 5.82e-79: 285: 14.89		TNPO2_HUMAN (214-1089): 4.77e-66: 242: 11.98
+	Sc
		691631 NUP2_YEAST (435-840): 1.31e-31: 135: 25.17		IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75
+	Sc
		767656 NU159_YEAST (347-936): 2.15e-17: 90.3: 14.33		IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75
+	Sc
		541885 NSP1_YEAST (511-1032): 4.79e-13: 75.7: 16.10		IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75
+	Hs
		127218 NU153_HUMAN (3-977): 5.82e-79: 285: 14.89		IPO5_HUMAN (3-679): 6.25e-18: 91.6: 10.34
+	Hs
		834599 NU153_HUMAN (3-977): 5.82e-79: 285: 14.89		IMB1_HUMAN (610-1085): 3.63e-16: 85.8: 10.82
+	Sc
		691667 NUP2_YEAST (435-840): 1.31e-31: 135: 25.17		IMB1_YEAST (14-701): 1.06e-46: 183: 15.89
+	Hs
		155553 NUP98_HUMAN (204-882): 2.45e-12: 73.8: 14.55		TNPO2_HUMAN (214-1089): 4.77e-66: 242: 11.98
+	Sc
		774378 NU159_YEAST (347-936): 2.15e-17: 90.3: 14.33		IMB1_YEAST (14-701): 1.06e-46: 183: 15.89
+	Sc
		541927 NSP1_YEAST (511-1032): 4.79e-13: 75.7: 16.10		IMB1_YEAST (14-701): 1.06e-46: 183: 15.89
+	Hs
		127345 P121A_HUMAN (51-1071): 1.05e-14: 81.4: 11.47		IPO5_HUMAN (3-679): 6.25e-18: 91.6: 10.34
+	Hs
		1060869 P121A_HUMAN (51-1071): 1.05e-14: 81.4: 11.47		IMB1_HUMAN (610-1085): 3.63e-16: 85.8: 10.82
+	Hs
		857978 NUP98_HUMAN (204-882): 2.45e-12: 73.8: 14.55		IMB1_HUMAN (610-1085): 3.63e-16: 85.8: 10.82