HitPredict

Interactor 1: ITAL (P20701)
Integrin alpha-L (CD11 antigen-like family member A) (Leukocyte adhesion glycoprotein LFA-1 alpha chain) (LFA-1A) (Leukocyte function-associated molecule 1 alpha chain) (CD antigen CD11a)
Gene: ITGAL

Interactor 2: ICAM3 (P32942)
Intercellular adhesion molecule 3 (ICAM-3) (CDw50) (ICAM-R) (CD antigen CD50)
Gene: ICAM3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15728350
Identification Methods	x-ray crystallography
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	ICAM_N~VWA
Common GO terms	GO:0005178 - integrin binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0006909 - phagocytosis GO:0070062 - extracellular exosome and 1 others more... GO:0098609 - cell-cell adhesion
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 1170 Hs			1 547
+	Hs
		399976 ITAL_HUMAN (1-1170): 0: 1242: 100.00		ICAM1_HUMAN (22-530): 2.97e-116: 356: 46.89
+	Hs
		399957 ITAM_HUMAN (1-1136): 0: 1055: 32.54		ICAM1_HUMAN (22-530): 2.97e-116: 356: 46.89
+	Hs
		701830 ITAD_HUMAN (16-1157): 0: 1036: 32.31		ICAM3_HUMAN (1-547): 7.47e-108: 334: 100.00
+	Hs
		581715 ITAD_HUMAN (16-1157): 0: 1036: 32.31		VCAM1_HUMAN (232-483): 5.01e-21: 99.3: 18.86
+	Hs
		126397 MATN2_HUMAN (148-422): 4.86e-50: 194: 21.83		PXDN_HUMAN (26-314): 5.71e-49: 184: 13.90
+	Hs
		530416 ITA4_HUMAN (3-591): 6.53e-52: 201: 15.01		VCAM1_HUMAN (232-483): 5.01e-21: 99.3: 18.86
+	Hs
		443037 ITA5_HUMAN (23-423): 1.31e-32: 139: 15.12		VCAM1_HUMAN (232-483): 5.01e-21: 99.3: 18.86