HitPredict

Interactor 1: NTF3 (P20783)
Neurotrophin-3 (NT-3) (HDNF) (Nerve growth factor 2) (NGF-2) (Neurotrophic factor)
Gene: NTF3

Interactor 2: NTRK2 (Q16620)
BDNF/NT-3 growth factors receptor (EC 2.7.10.1) (GP145-TrkB) (Trk-B) (Neurotrophic tyrosine kinase receptor type 2) (TrkB tyrosine kinase) (Tropomyosin-related kinase B)
Gene: NTRK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	8621424
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	I-set~NGF
Common GO terms	GO:0008284 - positive regulation of cell population proliferation GO:0030424 - axon GO:0030425 - dendrite GO:0033138 - positive regulation of peptidyl-serine phosphorylation GO:0043524 - negative regulation of neuron apoptotic process
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 257 Hs			1 822
+	Mm
		546282 NTF3_MOUSE (1-257): 1.41e-150: 421: 95.74		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Hs
		595718 NTF3_HUMAN (1-257): 8.59e-154: 430: 100.00		NTRK3_HUMAN (13-822): 1.98e-178: 536: 52.84
+	Hs
		595708 NTF3_HUMAN (1-257): 8.59e-154: 430: 100.00		FGFR4_HUMAN (152-820): 3.01e-178: 534: 24.68
+	Hs
		384249 NTF3_HUMAN (1-257): 8.59e-154: 430: 100.00		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85
+	Hs
		618271 BDNF_HUMAN (1-256): 2.8e-92: 274: 36.67		NTRK2_HUMAN (1-822): 0: 638: 100.00
+	Mm
		546283 BDNF_MOUSE (1-256): 9.47e-95: 280: 37.04		NTRK2_MOUSE (1-822): 0: 631: 93.92
+	Rn
		615512 BDNF_RAT (1-256): 2.19e-95: 281: 37.04		NTRK2_RAT (1-822): 0: 622: 93.55
+	Hs
		710107 NTF4_HUMAN (72-256): 9.08e-75: 228: 43.37		NTRK2_HUMAN (1-822): 0: 638: 100.00
+	Hs
		351485 NGF_HUMAN (1-256): 2.04e-118: 339: 41.63		NTRK1_HUMAN (5-822): 2.36e-170: 513: 45.85