HitPredict

Interactor 1: VPS33 (P20795)
Vacuolar protein sorting-associated protein 33 (Protein SLP1) (Vacuolar morphogenesis protein 5)
Gene: VPS33

Interactor 2: PEP12 (P32854)
Syntaxin PEP12 (Carboxypeptidase Y-deficient protein 12) (Vacuolar protein sorting-associated protein 6) (Vacuolar protein-targeting protein 13)
Gene: PEP12

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	1.00	0.806

Property	Details
Experiments	23051737, 15047864
Identification Methods	pull down, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SNARE~Sec1
Common GO terms	GO:0000329 - fungal-type vacuole membrane GO:0005829 - cytosol GO:0006886 - intracellular protein transport GO:0006896 - Golgi to vacuole transport GO:0048278 - vesicle docking
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 691 Sc			1 288
+	At
		1319858 KEULE_ARATH (41-690): 1.49e-153: 461: 14.05		SY121_ARATH (8-269): 3.2e-46: 160: 18.82
+	Hs
		1017732 SCFD1_HUMAN (41-691): 6.25e-137: 418: 14.20		STX4_HUMAN (31-288): 4.63e-45: 156: 18.15
+	Hs
		1027531 SCFD1_HUMAN (41-691): 6.25e-137: 418: 14.20		STX5_HUMAN (2-270): 2.69e-44: 155: 13.92
+	Hs
		178695 SCFD1_HUMAN (41-691): 6.25e-137: 418: 14.20		STX7_HUMAN (25-286): 2.11e-45: 155: 21.29
+	Hs
		119613 STXB3_HUMAN (47-690): 2.08e-124: 384: 11.45		STX2_HUMAN (14-288): 1.79e-55: 182: 20.14
+	Hs
		152168 SCFD1_HUMAN (41-691): 6.25e-137: 418: 14.20		STX16_HUMAN (35-267): 8.74e-42: 148: 20.17
+	Dm
		1096641 SLY1_DROME (41-691): 9.9e-124: 383: 13.04		Q7K0X9_DROME (25-286): 3.76e-54: 178: 23.88
+	Dm
		1096657 SLY1_DROME (41-691): 9.9e-124: 383: 13.04		Q9VU45_DROME (13-282): 1.95e-52: 174: 20.37
+	At
		1338394 SLY1_ARATH (38-690): 7.82e-122: 378: 13.47		SYP32_ARATH (7-286): 1.06e-51: 174: 15.26
+	Dm
		1096638 SLY1_DROME (41-691): 9.9e-124: 383: 13.04		STX5_DROME (8-271): 2.18e-47: 166: 13.70
+	Dm
		1096639 SLY1_DROME (41-691): 9.9e-124: 383: 13.04		STX1A_DROME (27-286): 2.2e-49: 166: 19.77
+	Hs
		699262 STXB2_HUMAN (41-563): 3.56e-116: 362: 13.95		STX2_HUMAN (14-288): 1.79e-55: 182: 20.14
+	Mm
		192851 STXB2_MOUSE (41-630): 3.02e-119: 370: 13.24		STX1A_MOUSE (1-287): 4.97e-52: 173: 17.59
+	Hs
		119633 STXB3_HUMAN (47-690): 2.08e-124: 384: 11.45		STX4_HUMAN (31-288): 4.63e-45: 156: 18.15
+	Mm
		936822 STXB3_MOUSE (49-690): 1.57e-122: 379: 10.93		STX4_MOUSE (31-288): 3.07e-45: 156: 19.31
+	Mm
		936823 STXB2_MOUSE (41-630): 3.02e-119: 370: 13.24		STX4_MOUSE (31-288): 3.07e-45: 156: 19.31
+	Hs
		1030174 SCFD1_HUMAN (41-691): 6.25e-137: 418: 14.20		STX3_HUMAN (74-288): 2e-23: 98.8: 22.58
+	Dm
		1096654 SLY1_DROME (41-691): 9.9e-124: 383: 13.04		Q9VR90_DROME (22-280): 5.01e-32: 123: 18.15
+	Mm
		1145332 STXB2_MOUSE (41-630): 3.02e-119: 370: 13.24		STX3_MOUSE (74-267): 8.45e-23: 96.9: 22.45
+	Hs
		1030144 STXB2_HUMAN (41-563): 3.56e-116: 362: 13.95		STX3_HUMAN (74-288): 2e-23: 98.8: 22.58