HitPredict

Interactor 1: HNF1A (P20823)
Hepatocyte nuclear factor 1-alpha (HNF-1-alpha) (HNF-1A) (Liver-specific transcription factor LF-B1) (LFB1) (Transcription factor 1) (TCF-1)
Gene: HNF1A

Interactor 2: PHS2 (Q9H0N5)
Pterin-4-alpha-carbinolamine dehydratase 2 (PHS 2) (EC 4.2.1.96) (4-alpha-hydroxy-tetrahydropterin dehydratase 2) (DcoH-like protein DCoHm) (Dimerization cofactor of hepatocyte nuclear factor 1 from muscle) (HNF-1-alpha dimerization cofactor)
Gene: PCBD2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	17353931, 33961781, 35140242, 11980910
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 631 Hs			1 130
+	Hs
		595917 HNF1A_HUMAN (1-631): 0: 635: 100.00		PHS_HUMAN (28-130): 8.31e-47: 148: 61.17
+	Mm
		607525 HNF1A_MOUSE (1-631): 0: 617: 94.61		PHS2_MOUSE (13-130): 9.33e-54: 166: 83.05
+	Mm
		607521 HNF1A_MOUSE (1-631): 0: 617: 94.61		PHS_MOUSE (28-130): 3.38e-47: 149: 60.19
+	Hs
		727585 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		PHS2_HUMAN (1-130): 2.3e-57: 175: 100.00
+	Mm
		655008 HNF1B_MOUSE (1-541): 1.04e-153: 456: 53.98		PHS_MOUSE (28-130): 3.38e-47: 149: 60.19
+	Hs
		727496 HNF1B_HUMAN (1-541): 1.27e-150: 448: 53.21		PHS_HUMAN (28-130): 8.31e-47: 148: 61.17