HitPredict

Interactor 1: NEBU (P20929)
Nebulin
Gene: NEB

Interactor 2: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	30021884
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0015629 - actin cytoskeleton GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 8525 Hs			1 375
+	Hs
		596210 NEBU_HUMAN (1-8525): 0: 8652: 100.00		ACTH_HUMAN (2-375): 0: 589: 93.58
+	Hs
		933013 NRAP_HUMAN (6777-8419): 3.73e-150: 519: 19.14		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Hs
		891755 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929856 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932145 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		932975 SPTN1_HUMAN (7876-8525): 2.1e-58: 229: 11.33		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Sc
		887671 MYO5_YEAST (7954-8524): 1.16e-56: 221: 12.75		ACT_YEAST (1-375): 0: 591: 88.80
+	Hs
		930053 PACN2_HUMAN (8069-8525): 3.87e-54: 202: 13.94		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		892099 DBNL_HUMAN (8296-8525): 1.37e-35: 145: 20.78		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932439 DBNL_HUMAN (8296-8525): 1.37e-35: 145: 20.78		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		235496 VINEX_HUMAN (8153-8525): 1.64e-33: 143: 11.63		ACTS_HUMAN (2-375): 0: 592: 93.58
+	Sc
		887646 NUM1_YEAST (6851-8386): 1.22e-30: 137: 12.58		ACT_YEAST (1-375): 0: 591: 88.80
+	Hs
		892005 SRBS1_HUMAN (8368-8525): 5.41e-27: 125: 20.23		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		932362 SRBS1_HUMAN (8368-8525): 5.41e-27: 125: 20.23		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		282322 NEBL_HUMAN (7761-8471): 8.74e-21: 104: 19.46		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		891762 SRC8_HUMAN (8096-8488): 8.57e-18: 93.5: 11.51		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Hs
		929863 SRC8_HUMAN (8096-8488): 8.57e-18: 93.5: 11.51		ACTG_HUMAN (1-375): 0: 601: 98.93
+	Hs
		932154 SRC8_HUMAN (8096-8488): 8.57e-18: 93.5: 11.51		ACTC_HUMAN (2-375): 0: 592: 94.12
+	Hs
		891770 LASP1_HUMAN (5895-6038): 2.35e-10: 67.3: 18.06		ACTB_HUMAN (1-375): 0: 603: 100.00
+	Dm
		361146 LASP1_DROME (7702-7839): 3.81e-09: 66.2: 20.86		ACT2_DROME (2-375): 0: 596: 97.59