HitPredict

Interactor 1: FILA (P20930)
Filaggrin
Gene: FLG

Interactor 2: FILA2 (Q5D862)
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)
Gene: FLG2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	24981860
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	S_100~S_100
Common GO terms	GO:0001533 - cornified envelope GO:0005509 - calcium ion binding GO:0005634 - nucleus GO:0036457 - keratohyalin granule GO:0046914 - transition metal ion binding and 1 others more... GO:0061436 - establishment of skin barrier
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 4061 Hs			1 2391
+	Hs
		358648 CO4A2_HUMAN (3241-4046): 4.47e-44: 180: 8.51		CO4A1_HUMAN (1520-2391): 3.03e-43: 176: 9.29
+	Rn
		358576 CO1A2_RAT (116-737): 4.54e-46: 186: 10.05		CO1A1_RAT (202-1339): 3.91e-37: 156: 10.98
+	Dm
		435987 CO4A1_DROME (94-852): 2.42e-56: 220: 8.59		Q9VMV5_DROME (2007-2376): 3.06e-24: 114: 10.11
+	Hs
		615200 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S10A1_HUMAN (2-93): 2.13e-45: 161: 36.96
+	Hs
		1135040 Q5T7Y6_HUMAN (2-92): 7.46e-45: 162: 35.17		Q5T7Y6_HUMAN (2-93): 1.17e-44: 161: 36.96
+	Hs
		380736 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S100B_HUMAN (1-92): 2.49e-44: 158: 36.96
+	Hs
		380713 S100B_HUMAN (1-92): 9.63e-46: 162: 34.78		S100B_HUMAN (1-92): 2.49e-44: 158: 36.96
+	Hs
		380790 Q5T7Y6_HUMAN (2-92): 7.46e-45: 162: 35.17		S100B_HUMAN (1-92): 2.49e-44: 158: 36.96
+	Hs
		615201 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S100P_HUMAN (1-95): 1.9e-43: 155: 41.05
+	Hs
		638981 Q5T7Y6_HUMAN (2-92): 7.46e-45: 162: 35.17		S100P_HUMAN (1-95): 1.9e-43: 155: 41.05
+	Hs
		380717 S100B_HUMAN (1-92): 9.63e-46: 162: 34.78		S10A9_HUMAN (1-109): 6.76e-42: 151: 30.91
+	Hs
		615203 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S10A4_HUMAN (3-101): 5.85e-41: 148: 29.29
+	Hs
		1125327 FILA2_HUMAN (1661-4000): 4.12e-60: 233: 20.51		HORN_HUMAN (1590-2390): 3.13e-13: 78: 17.93
+	Hs
		615222 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S100Z_HUMAN (2-92): 1.66e-40: 147: 37.36
+	Hs
		441046 CO4A2_HUMAN (3241-4046): 4.47e-44: 180: 8.51		CO4A2_HUMAN (1703-2388): 8.9e-29: 129: 10.35
+	Hs
		615204 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S10A2_HUMAN (2-91): 8.89e-40: 145: 32.22
+	Hs
		380718 S100B_HUMAN (1-92): 9.63e-46: 162: 34.78		S10A6_HUMAN (4-90): 3.33e-27: 109: 31.03
+	Hs
		615206 S10A1_HUMAN (2-93): 2.08e-46: 164: 34.78		S10A3_HUMAN (4-98): 1.25e-21: 93.6: 26.32