HitPredict

Interactor 1: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Interactor 2: CSK (P41240)
Tyrosine-protein kinase CSK (EC 2.7.10.2) (C-Src kinase) (Protein-tyrosine kinase CYL)
Gene: CSK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	7544435
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	C2~SH2, PH~PK_Tyr_Ser-Thr, PH~SH3_1, PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1, PK_Tyr_Ser-Thr~SH3_1, SH3_1~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1047 Hs			1 450
+	Hs
		337344 RASA1_HUMAN (1-1047): 0: 824: 100.00		ABL1_HUMAN (5-447): 1.78e-164: 494: 37.83
+	Mm
		93302 E9PYG6_MOUSE (1-1047): 0: 823: 95.03		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Hs
		522768 RASA1_HUMAN (1-1047): 0: 824: 100.00		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433252 RASA1_HUMAN (1-1047): 0: 824: 100.00		YES_HUMAN (12-442): 5.99e-170: 490: 37.30
+	Hs
		411591 RASA1_HUMAN (1-1047): 0: 824: 100.00		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		442777 RASA1_HUMAN (1-1047): 0: 824: 100.00		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		433821 DAB2P_HUMAN (491-1046): 1.09e-126: 417: 25.62		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		411884 NGAP_HUMAN (492-1040): 9.8e-115: 383: 24.83		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		412315 SYGP1_HUMAN (375-1030): 6.69e-106: 362: 19.45		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		442830 RASA3_HUMAN (491-991): 2.93e-112: 369: 21.93		HCK_HUMAN (3-445): 6.38e-167: 481: 36.32
+	Hs
		434065 NGAP_HUMAN (492-1040): 9.8e-115: 383: 24.83		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		433762 RASA3_HUMAN (491-991): 2.93e-112: 369: 21.93		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		522851 IQGA1_HUMAN (394-1044): 2.98e-94: 331: 12.78		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33
+	Hs
		433641 IQGA1_HUMAN (394-1044): 2.98e-94: 331: 12.78		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		411593 NF1_HUMAN (720-1040): 4.33e-81: 293: 24.44		LCK_HUMAN (5-443): 1.95e-168: 485: 38.55
+	Hs
		433751 IQGA2_HUMAN (460-1044): 2.27e-84: 301: 13.18		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Hs
		433572 NF1_HUMAN (720-1040): 4.33e-81: 293: 24.44		LYN_HUMAN (4-445): 3.75e-160: 463: 37.12
+	Mm
		337619 PTN11_MOUSE (346-428): 1.05e-19: 96.4: 34.94		ABL1_MOUSE (5-447): 5.69e-165: 495: 37.83
+	Hs
		412146 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		FYN_HUMAN (12-442): 1.26e-170: 491: 36.77
+	Hs
		522931 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		SRC_HUMAN (12-442): 8.48e-171: 491: 39.33