HitPredict

Interactor 1: RASA1 (P20936)
Ras GTPase-activating protein 1 (GAP) (GTPase-activating protein) (RasGAP) (Ras p21 protein activator) (p120GAP)
Gene: RASA1

Interactor 2: DOK1 (Q99704)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok)) (pp62)
Gene: DOK1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.966

Property	Details
Experiments	10822173, 10799545, 9478921, 15151996, 9008161, 22974441, 9822717, 11551902, 10688886
Identification Methods	affinity chromatography technology, unspecified method, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	IRS~PH, PH~PH, PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1047 Hs			1 481
+	Mm
		93305 E9PYG6_MOUSE (1-1047): 0: 823: 95.03		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Rn
		842411 RASA1_RAT (1-1047): 0: 811: 94.65		DOK1_RAT (1-481): 0: 559: 83.99
+	Mm
		93301 E9PYG6_MOUSE (1-1047): 0: 823: 95.03		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Hs
		235043 RASA1_HUMAN (1-1047): 0: 824: 100.00		DOK2_HUMAN (2-426): 3.33e-116: 349: 34.09
+	Hs
		986022 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		DOK1_HUMAN (1-481): 0: 564: 100.00
+	Mm
		956523 Q91YX7_MOUSE (168-596): 5.49e-16: 85.1: 12.14		DOK1_MOUSE (1-481): 0: 549: 83.23
+	Mm
		250956 Q91YX7_MOUSE (168-596): 5.49e-16: 85.1: 12.14		DOK2_MOUSE (2-426): 3.12e-118: 354: 31.31
+	Rn
		724630 PTN11_RAT (168-347): 1.18e-25: 115: 24.63		IRS1_RAT (6-373): 3.69e-78: 267: 17.27
+	Hs
		151763 GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71		IRS4_HUMAN (6-404): 5.55e-95: 314: 14.35
+	Hs
		724535 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Rn
		94387 PTN11_RAT (168-347): 1.18e-25: 115: 24.63		F1MAL5_RAT (6-371): 8.44e-69: 240: 15.10
+	Hs
		986064 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		IRS2_HUMAN (6-384): 1.12e-67: 237: 14.05
+	Rn
		724631 GRB2_RAT (181-317): 1.08e-10: 64.3: 30.71		IRS1_RAT (6-373): 3.69e-78: 267: 17.27
+	Hs
		724527 GRB2_HUMAN (181-317): 1.08e-10: 64.3: 30.71		IRS1_HUMAN (6-373): 1.95e-76: 262: 16.33
+	Rn
		88883 PTN11_RAT (168-347): 1.18e-25: 115: 24.63		D4A244_RAT (154-464): 1.16e-58: 203: 22.68
+	Rn
		94388 GRB2_RAT (181-317): 1.08e-10: 64.3: 30.71		F1MAL5_RAT (6-371): 8.44e-69: 240: 15.10
+	Mm
		719314 PTN11_MOUSE (346-428): 1.05e-19: 96.4: 34.94		FRS2_MOUSE (154-464): 4.46e-56: 196: 21.73
+	Hs
		985997 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		FRS2_HUMAN (154-464): 2.53e-54: 191: 21.09
+	Hs
		207310 PTN11_HUMAN (346-428): 1.05e-19: 96.4: 34.94		FRS3_HUMAN (153-432): 4e-52: 185: 20.42
+	Rn
		88884 GRB2_RAT (181-317): 1.08e-10: 64.3: 30.71		D4A244_RAT (154-464): 1.16e-58: 203: 22.68