HitPredict

Interactor 1: CD3Z (P20963)
T-cell surface glycoprotein CD3 zeta chain (T-cell receptor T3 zeta chain) (CD antigen CD247)
Gene: CD247

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	8647168, 7544002
Identification Methods	affinity chromatography technology, nuclear magnetic resonance
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 164 Hs			1 583
+	Hs
		596585 CD3Z_HUMAN (1-164): 4.87e-98: 281: 100.00		SHC3_HUMAN (6-582): 3.32e-127: 387: 45.47
+	Mm
		621828 CD3Z_MOUSE (1-164): 1.34e-98: 282: 81.10		VAV_MOUSE (163-579): 6.29e-54: 198: 11.54
+	Hs
		557602 CD3Z_HUMAN (1-164): 4.87e-98: 281: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		596499 CD3Z_HUMAN (1-164): 4.87e-98: 281: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31