HitPredict

Interactor 1: CD11B (P21127)
Cyclin-dependent kinase 11B (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 1) (CLK-1) (Cell division protein kinase 11B) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L1) (p58 CLK-1)
Gene: CDK11B

Interactor 2: CCNL1 (Q9UK58)
Cyclin-L1 (Cyclin-L)
Gene: CCNL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0000307 - cyclin-dependent protein kinase holoenzyme complex GO:0005634 - nucleus GO:0042981 - regulation of apoptotic process GO:0043484 - regulation of RNA splicing GO:0046605 - regulation of centrosome cycle and 1 others more... GO:0051726 - regulation of cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 795 Hs			1 526
+	Hs
		1356304 CD11A_HUMAN (1-795): 0: 561: 96.86		CCNL1_HUMAN (1-526): 2.58e-109: 337: 100.00
+	Hs
		1301925 CD11A_HUMAN (1-795): 0: 561: 96.86		CCNL2_HUMAN (39-526): 6.46e-97: 305: 58.49
+	Hs
		236695 CD11B_HUMAN (1-795): 0: 574: 100.00		CCNT1_HUMAN (53-526): 1.39e-88: 289: 17.59
+	Hs
		237380 CD11B_HUMAN (1-795): 0: 574: 100.00		CCNT2_HUMAN (55-526): 1.56e-84: 278: 19.83
+	Hs
		538471 CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96		CCNB1_HUMAN (7-328): 8.11e-92: 289: 14.37
+	At
		1210030 CDKC2_ARATH (425-792): 5.28e-136: 414: 40.73		CCT14_ARATH (38-524): 6.1e-104: 324: 20.97
+	Hs
		303829 CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96		CCNB2_HUMAN (3-331): 1.23e-86: 274: 13.68
+	Hs
		625350 CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96		CCNA1_HUMAN (16-321): 1.03e-85: 274: 16.56
+	Hs
		538521 CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64		CCNB1_HUMAN (7-328): 8.11e-92: 289: 14.37
+	At
		1247203 Q9CAG1_ARATH (34-774): 6.12e-144: 443: 34.57		CCL11_ARATH (50-492): 1.63e-79: 256: 34.08
+	Mm
		956329 CDK2_MOUSE (435-731): 8.4e-145: 431: 38.15		CCNA1_MOUSE (16-322): 4.39e-83: 265: 15.53
+	At
		1108309 Q9CAG1_ARATH (34-774): 6.12e-144: 443: 34.57		CCA34_ARATH (5-322): 1.66e-76: 247: 12.23
+	Gg
		533892 CDK1_CHICK (435-735): 3.59e-140: 417: 40.92		CCNB2_CHICK (8-328): 3.34e-84: 268: 13.40
+	Xl
		526765 CDK1A_XENLA (435-735): 1.25e-139: 416: 40.92		CCNB1_XENLA (10-323): 9.18e-84: 267: 14.51
+	At
		1247204 CDKG1_ARATH (171-742): 7.21e-139: 425: 37.33		CCL11_ARATH (50-492): 1.63e-79: 256: 34.08
+	Hs
		960107 CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64		CCNQ_HUMAN (79-290): 2.47e-72: 232: 29.02
+	Hs
		624422 CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64		CCNC_HUMAN (37-334): 2.01e-71: 231: 23.41
+	Mm
		956332 CDK2_MOUSE (435-731): 8.4e-145: 431: 38.15		CCNC_MOUSE (37-334): 4.62e-71: 230: 23.41
+	Hs
		625251 CDK2_HUMAN (435-731): 1.45e-154: 454: 43.96		CCNH_HUMAN (74-339): 1.91e-56: 193: 17.39
+	Hs
		851197 CDK3_HUMAN (435-731): 8.54e-148: 436: 45.64		CCNH_HUMAN (74-339): 1.91e-56: 193: 17.39