HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: PSB6 (P23724)
Proteasome subunit beta type-6 (Multicatalytic endopeptidase complex subunit C5) (Proteasome component C5)
Gene: PRE7

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	1.00	0.839

Property	Details
Experiments	16554755, 37968396, 22940862
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 252 Sc			1 241
+	Hs
		893636 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSA6_HUMAN (6-241): 1.39e-74: 228: 18.75
+	Dm
		771303 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSA5_DROME (6-241): 1.55e-71: 220: 18.62
+	Hs
		156266 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSA7_HUMAN (6-241): 3.52e-73: 224: 18.75
+	Dm
		574014 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSA4_DROME (6-240): 3.11e-70: 217: 16.81
+	Sc
		597290 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		PSB3_YEAST (22-241): 4.13e-67: 207: 22.87
+	Dm
		771329 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSA6_DROME (6-240): 1.89e-70: 217: 15.97
+	Hs
		638100 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSA4_HUMAN (6-240): 1.63e-72: 223: 16.32
+	Hs
		656189 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSA5_HUMAN (6-241): 3.71e-71: 219: 17.14
+	Sc
		597296 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		PSB5_YEAST (27-231): 1.32e-62: 198: 19.02
+	Dm
		771294 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		Q7K148_DROME (6-231): 2.9e-65: 205: 18.58
+	Hs
		656051 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB8_HUMAN (18-233): 1.21e-67: 211: 19.44
+	Hs
		594497 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB1_HUMAN (10-241): 1.9e-67: 209: 44.83
+	Dm
		771285 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSB1_DROME (21-241): 8.9e-64: 200: 39.37
+	Hs
		831968 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB3_HUMAN (25-241): 3.42e-66: 205: 21.82
+	Hs
		656692 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB5_HUMAN (27-233): 1.88e-64: 202: 20.29
+	Dm
		47598 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		A0AQH0_DROME (28-236): 4.5e-59: 187: 24.88
+	Dm
		771328 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSB3_DROME (26-241): 4.17e-59: 187: 19.64
+	Sc
		597315 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		PSB1_YEAST (28-236): 2e-51: 167: 22.01
+	Hs
		656580 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB6_HUMAN (28-236): 6.19e-49: 162: 22.97
+	Hs
		656102 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB9_HUMAN (28-236): 1.79e-42: 145: 21.53