HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: PSB3 (P25451)
Proteasome subunit beta type-3 (Macropain subunit PUP3) (Multicatalytic endopeptidase complex subunit PUP3) (Proteasome component PUP3)
Gene: PUP3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.896

Property	Details
Experiments	11805826, 16554755, 16429126, 37968396
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Proteasome~Proteasome, Proteasome~Proteasome_A_N
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0010499 - proteasomal ubiquitin-independent protein catabolic process GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 252 Sc			1 205
+	Sc
		597287 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		PSB6_YEAST (3-205): 1.03e-73: 224: 22.52
+	Dm
		771285 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSB1_DROME (4-205): 1.85e-76: 231: 30.37
+	Sc
		597296 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		PSB5_YEAST (4-195): 1.16e-64: 203: 22.80
+	Dm
		771294 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		Q7K148_DROME (4-205): 1.88e-67: 209: 23.65
+	Hs
		656051 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB8_HUMAN (4-205): 3.16e-69: 214: 23.65
+	Hs
		656692 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB5_HUMAN (8-205): 2.72e-67: 208: 21.11
+	Dm
		771328 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSB3_DROME (7-205): 6.25e-65: 200: 54.50
+	Dm
		771303 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSA5_DROME (6-205): 7.81e-64: 199: 18.87
+	Dm
		771302 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		Q8T8V8_DROME (7-196): 2.31e-61: 195: 19.90
+	Dm
		184454 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		O17311_DROME (6-196): 1.82e-61: 194: 18.75
+	Hs
		656189 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSA5_HUMAN (6-205): 1.89e-64: 200: 17.14
+	Hs
		831968 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB3_HUMAN (3-205): 5e-64: 198: 53.43
+	Hs
		594497 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB1_HUMAN (3-205): 9.86e-63: 196: 23.47
+	Af
		191426 PSA_ARCFU (11-251): 3.1e-94: 278: 32.51		PSB_ARCFU (6-205): 1.62e-66: 204: 26.37
+	At
		286453 PSA6B_ARATH (5-252): 1e-95: 282: 48.80		PSB7B_ARATH (5-205): 1.88e-61: 194: 19.31
+	At
		188701 PSA6B_ARATH (5-252): 1e-95: 282: 48.80		PSB7A_ARATH (5-205): 2.79e-61: 193: 18.81
+	Ph
		223381 PSA_PYRHO (9-246): 4.62e-96: 283: 33.75		PSB1_PYRHO (5-202): 1.33e-59: 186: 21.50
+	Dm
		47598 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		A0AQH0_DROME (1-200): 1.38e-30: 113: 20.40
+	Hs
		656102 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB9_HUMAN (5-200): 6.23e-30: 111: 20.81
+	Hs
		656580 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSB6_HUMAN (5-200): 1.04e-28: 108: 18.78