HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: RPN2 (P32565)
26S proteasome regulatory subunit RPN2
Gene: RPN2

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	18511945, 16429126, 37968396
Identification Methods	pull down, affinity chromatography technology, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 252 Sc			1 945
+	Hs
		893734 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		156342 PSA7_HUMAN (11-246): 1.3e-92: 274: 29.96		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		656297 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		638180 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		PSMD1_HUMAN (3-926): 0: 1116: 39.98
+	Hs
		699 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Dm
		771308 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSMD1_DROME (1-927): 0: 990: 36.04
+	Hs
		689 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Hs
		688 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Hs
		686 PSA2_HUMAN (10-249): 1.69e-88: 263: 29.58		A0A087WW66_HUMAN (3-926): 0: 1016: 36.69
+	Dm
		1359022 PSA6_DROME (5-252): 7.43e-94: 277: 48.00		PSMD1_DROME (1-927): 0: 990: 36.04
+	Dm
		1278636 PSA5_DROME (8-249): 1.59e-91: 271: 24.80		PSMD1_DROME (1-927): 0: 990: 36.04
+	Hs
		893662 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		156281 PSA7_HUMAN (11-246): 1.3e-92: 274: 29.96		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		656214 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Hs
		638122 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		PSMD2_HUMAN (9-770): 0: 760: 17.31
+	Dm
		771325 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		Q9VW54_DROME (13-770): 0: 651: 17.61
+	Dm
		1375003 PSA6_DROME (5-252): 7.43e-94: 277: 48.00		Q9VW54_DROME (13-770): 0: 651: 17.61
+	Dm
		1278652 PSA5_DROME (8-249): 1.59e-91: 271: 24.80		Q9VW54_DROME (13-770): 0: 651: 17.61
+	Sp
		953217 PSA5_SCHPO (8-251): 3.2e-90: 268: 24.80		RPN1_SCHPO (9-770): 0: 621: 18.33
+	Sc
		597317 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		RPN1_YEAST (9-573): 1.13e-134: 430: 17.33