HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: RPN10 (P38886)
26S proteasome regulatory subunit RPN10
Gene: RPN10

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	11805826, 37968396, 16429126
Identification Methods	tandem affinity purification, affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 252 Sc			1 268
+	Hs
		874058 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		893687 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15
+	Hs
		156262 PSA7_HUMAN (11-246): 1.3e-92: 274: 29.96		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		656185 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		656250 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15
+	Hs
		638097 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		638147 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		Q5VWC4_HUMAN (1-236): 7.75e-119: 346: 49.15
+	Hs
		637658 PSA2_HUMAN (10-249): 1.69e-88: 263: 29.58		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Hs
		637824 PSA3_HUMAN (9-183): 1.69e-28: 110: 36.00		PSMD4_HUMAN (1-236): 5.46e-119: 347: 49.15
+	Sc
		597236 PSA7_YEAST (9-183): 3.03e-28: 110: 37.14		RPN10_YEAST (1-268): 3.42e-114: 330: 100.00