HitPredict

Interactor 1: PSA1 (P21243)
Proteasome subunit alpha type-1 (Macropain subunit C7-alpha) (Multicatalytic endopeptidase complex C7) (Proteasome component C7-alpha) (Proteasome component Y8) (Proteinase YSCE subunit 7) (SCL1 suppressor protein)
Gene: SCL1

Interactor 2: RPN11 (P43588)
Ubiquitin carboxyl-terminal hydrolase RPN11 (EC 3.4.19.12) (26S proteasome regulatory subunit RPN11) (Protein MPR1)
Gene: RPN11

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.751

Property	Details
Experiments	22037170, 16284124, 22215586, 24038880, 37968396, 21321079, 21627799, 21658604, 23770819, 22927375
Identification Methods	pull down, affinity chromatography technology, biochemical
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 252 Sc			1 306
+	Dm
		771306 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSDE_DROME (1-306): 6.79e-103: 305: 64.29
+	Sp
		293562 PSA1_SCHPO (7-252): 1.36e-103: 302: 56.28		RPN11_SCHPO (1-305): 3.11e-95: 285: 64.29
+	Hs
		130824 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Dm
		1278634 PSA5_DROME (8-249): 1.59e-91: 271: 24.80		PSDE_DROME (1-306): 6.79e-103: 305: 64.29
+	Hs
		130644 PSA7_HUMAN (11-246): 1.3e-92: 274: 29.96		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130754 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130749 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Hs
		130747 PSA2_HUMAN (10-249): 1.69e-88: 263: 29.58		PSDE_HUMAN (16-306): 2.53e-98: 293: 67.35
+	Sp
		784781 PSA5_SCHPO (8-251): 3.2e-90: 268: 24.80		RPN11_SCHPO (1-305): 3.11e-95: 285: 64.29
+	Hs
		893720 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Hs
		156334 PSA7_HUMAN (11-246): 1.3e-92: 274: 29.96		CSN5_HUMAN (14-292): 7.24e-75: 234: 30.74
+	Sc
		597351 PSA1_YEAST (12-252): 5.08e-106: 308: 100.00		RPN8_YEAST (25-305): 6.68e-51: 172: 16.03
+	Dm
		640767 PSA2_DROME (11-248): 2.48e-102: 298: 28.57		PSMD7_DROME (23-305): 1.03e-43: 154: 15.57
+	Dm
		640776 PSA5_DROME (8-249): 1.59e-91: 271: 24.80		PSMD7_DROME (23-305): 1.03e-43: 154: 15.57
+	Dm
		1358670 PSA3_DROME (9-200): 2.94e-31: 117: 34.38		PSDE_DROME (1-306): 6.79e-103: 305: 64.29
+	Hs
		849173 PSA6_HUMAN (5-252): 3.52e-99: 291: 53.20		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		656177 PSA5_HUMAN (8-248): 5.93e-91: 270: 24.70		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		638089 PSA4_HUMAN (9-245): 3.47e-89: 266: 26.75		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Hs
		637651 PSA2_HUMAN (10-249): 1.69e-88: 263: 29.58		PSMD7_HUMAN (23-149): 5.65e-31: 120: 24.06
+	Dm
		640785 PSA3_DROME (9-200): 2.94e-31: 117: 34.38		PSMD7_DROME (23-305): 1.03e-43: 154: 15.57