HitPredict

Interactor 1: VATB2 (P21281)
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)
Gene: ATP6V1B2

Interactor 2: VATC2 (Q8NEY4)
V-type proton ATPase subunit C 2 (V-ATPase subunit C 2) (Vacuolar proton pump subunit C 2)
Gene: ATP6V1C2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26186194, 26496610, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 511 Hs			1 427
+	Mm
		1265224 VATB1_MOUSE (28-510): 0: 595: 87.79		VATC2_MOUSE (1-427): 0: 583: 91.80
+	Hs
		547344 VATB1_HUMAN (25-509): 0: 599: 88.25		VATC2_HUMAN (1-427): 0: 574: 100.00
+	Hs
		597638 VATB2_HUMAN (1-511): 0: 644: 100.00		VATC1_HUMAN (1-427): 1.67e-179: 507: 55.61
+	Hs
		547309 VATB1_HUMAN (25-509): 0: 599: 88.25		VATC1_HUMAN (1-427): 1.67e-179: 507: 55.61
+	Mm
		1265229 VATB1_MOUSE (28-510): 0: 595: 87.79		VATC1_MOUSE (1-427): 9.17e-179: 505: 55.61
+	Sc
		555879 VATB_YEAST (34-504): 0: 575: 80.68		VATC_YEAST (7-423): 8.37e-135: 394: 30.73
+	Dm
		680172 VATB_DROME (24-508): 0: 599: 89.92		VATC_DROME (1-96): 2.6e-32: 131: 56.70