HitPredict

Interactor 1: VATB2 (P21281)
V-type proton ATPase subunit B, brain isoform (V-ATPase subunit B 2) (Endomembrane proton pump 58 kDa subunit) (HO57) (Vacuolar proton pump subunit B 2)
Gene: ATP6V1B2

Interactor 2: VATH (Q9UI12)
V-type proton ATPase subunit H (V-ATPase subunit H) (Nef-binding protein 1) (NBP1) (Protein VMA13 homolog) (V-ATPase 50/57 kDa subunits) (Vacuolar proton pump subunit H) (Vacuolar proton pump subunit SFD)
Gene: ATP6V1H

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.656

The method score is based on:

Property	Details
Experiments	35271311, 33961781, 37071682
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000221 - vacuolar proton-transporting V-type ATPase, V1 domain GO:0005765 - lysosomal membrane GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007035 - vacuolar acidification and 7 others more... GO:0016241 - regulation of macroautophagy GO:0030665 - clathrin-coated vesicle membrane GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:0070062 - extracellular exosome GO:0097401 - synaptic vesicle lumen acidification GO:0098850 - extrinsic component of synaptic vesicle membrane GO:1902600 - proton transmembrane transport
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1	511
Hs

1	483

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024