HitPredict

Interactor 1: VATC1 (P21283)
V-type proton ATPase subunit C 1 (V-ATPase subunit C 1) (Vacuolar proton pump subunit C 1)
Gene: ATP6V1C1

Interactor 2: VPP2 (Q9Y487)
V-type proton ATPase 116 kDa subunit a 2 (V-ATPase 116 kDa subunit a 2) (Lysosomal H(+)-transporting ATPase V0 subunit a 2) (TJ6) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2)
Gene: ATP6V0A2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	V-ATPase_C~V_ATPase_I
Common GO terms	GO:0005765 - lysosomal membrane GO:0005886 - plasma membrane GO:0016241 - regulation of macroautophagy GO:0046961 - proton-transporting ATPase activity, rotational mechanism GO:1902495 - transmembrane transporter complex and 1 others more... GO:1902600 - proton transmembrane transport
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 382 Hs			1 856
+	Hs
		597741 VATC1_HUMAN (1-382): 0: 561: 100.00		VPP1_HUMAN (1-842): 0: 1278: 53.19
+	Hs
		597743 VATC1_HUMAN (1-382): 0: 561: 100.00		VPP4_HUMAN (1-843): 0: 1227: 51.89
+	Ce
		675343 VATC_CAEEL (3-380): 7.46e-173: 488: 56.20		VPP1_CAEEL (4-848): 0: 1177: 44.11
+	Hs
		597733 VATC1_HUMAN (1-382): 0: 561: 100.00		VPP3_HUMAN (1-843): 0: 1082: 49.35
+	Ce
		108380 VATC_CAEEL (3-380): 7.46e-173: 488: 56.20		VPP3_CAEEL (1-845): 0: 1081: 39.07
+	Ce
		106909 VATC_CAEEL (3-380): 7.46e-173: 488: 56.20		VPP2_CAEEL (1-843): 0: 1075: 39.39
+	Sc
		680264 VATC_YEAST (7-376): 2.56e-143: 414: 36.87		VPP1_YEAST (3-842): 0: 1037: 36.46
+	Sc
		680270 VATC_YEAST (7-376): 2.56e-143: 414: 36.87		VPP2_YEAST (3-845): 0: 947: 33.19