HitPredict

Interactor 1: CSRP1 (P21291)
Cysteine and glycine-rich protein 1 (Cysteine-rich protein 1) (CRP) (CRP1) (Epididymis luminal protein 141) (HEL-141)
Gene: CSRP1

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21706016
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 217
+	Hs
		924889 PDLI7_HUMAN (68-190): 3.94e-26: 105: 16.54		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924925 LIMA1_HUMAN (3-117): 9.06e-21: 91: 27.83		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		300996 ABLM3_HUMAN (7-169): 1.17e-20: 90.5: 14.97		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		150552 ABLM1_HUMAN (119-192): 6.1e-14: 71.2: 27.03		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		411641 PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42		LCK_HUMAN (3-202): 3.69e-37: 137: 28.91
+	Hs
		111447 PDLI7_HUMAN (68-190): 3.94e-26: 105: 16.54		J3QRU1_HUMAN (52-215): 3.95e-13: 69.6: 14.29
+	Hs
		433484 PDLI7_HUMAN (68-190): 3.94e-26: 105: 16.54		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		254384 LDB3_HUMAN (7-126): 1.19e-25: 105: 13.93		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Ce
		107567 G5EFG1_CAEEL (67-193): 3.21e-22: 95.1: 15.00		SRC2_CAEEL (118-215): 1.65e-14: 73.4: 22.00
+	Hs
		433500 LIMA1_HUMAN (3-117): 9.06e-21: 91: 27.83		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		337635 PAXI_MOUSE (6-67): 2.13e-11: 63.5: 29.03		ABL1_MOUSE (4-139): 4.07e-22: 95.9: 35.46
+	Hs
		337395 PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		434057 LIMA1_HUMAN (3-117): 9.06e-21: 91: 27.83		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		433853 MICA3_HUMAN (3-118): 4.43e-18: 83.3: 27.94		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		150515 ABLM1_HUMAN (119-192): 6.1e-14: 71.2: 27.03		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		150611 ABLM1_HUMAN (119-192): 6.1e-14: 71.2: 27.03		Q96D37_HUMAN (2-60): 8.82e-15: 74.6: 42.37
+	Hs
		150505 ABLM1_HUMAN (119-192): 6.1e-14: 71.2: 27.03		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		412085 PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433288 PAXI_HUMAN (6-67): 2.97e-11: 63.1: 27.42		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Mm
		403454 PAXI_MOUSE (6-67): 2.13e-11: 63.5: 29.03		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58