HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: BRCA1 (P38398)
Breast cancer type 1 susceptibility protein (EC 2.3.2.27) (RING finger protein 53) (RING-type E3 ubiquitin transferase BRCA1)
Gene: BRCA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	20305393, 26831064, 22990118
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 1863
+	Hs
		261214 FLNB_HUMAN (28-2647): 0: 2710: 69.63		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		598234 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MCPH1_HUMAN (1150-1857): 1.33e-95: 331: 14.19
+	Hs
		62677 FLNA_HUMAN (1-2647): 0: 2776: 100.00		TRI64_HUMAN (12-413): 3.39e-71: 248: 11.55
+	Hs
		598309 FLNA_HUMAN (1-2647): 0: 2776: 100.00		TRIM6_HUMAN (10-377): 5.59e-67: 237: 13.54
+	Hs
		749493 FLNC_HUMAN (32-2647): 0: 1432: 35.96		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749382 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		749416 ACTN3_HUMAN (30-460): 2.85e-118: 401: 25.28		BRCA1_HUMAN (1-1863): 0: 1570: 100.00
+	Hs
		521464 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		RO52_HUMAN (15-390): 2.55e-68: 241: 12.86
+	Hs
		62673 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		TRI64_HUMAN (12-413): 3.39e-71: 248: 11.55
+	Hs
		211495 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		RO52_HUMAN (15-390): 2.55e-68: 241: 12.86