HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: MTR1B (P49286)
Melatonin receptor type 1B (Mel-1B-R) (Mel1b receptor)
Gene: MTNR1B

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.614

Property	Details
Experiments	26514267, 17215244
Identification Methods	pull down, two hybrid, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 362
+	Hs
		825709 Q60FE5_HUMAN (28-2647): 0: 2767: 100.00		MTR1B_HUMAN (1-362): 9.76e-84: 260: 100.00
+	Hs
		428914 FLNA_HUMAN (1-2647): 0: 2776: 100.00		ADRB2_HUMAN (1-347): 1.24e-78: 248: 17.55
+	Hs
		597983 FLNA_HUMAN (1-2647): 0: 2776: 100.00		OPRM_HUMAN (5-362): 2.06e-73: 234: 20.39
+	Hs
		598004 FLNA_HUMAN (1-2647): 0: 2776: 100.00		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		815890 Q60FE5_HUMAN (28-2647): 0: 2767: 100.00		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38
+	Hs
		723009 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1B_HUMAN (3-327): 2.24e-76: 245: 22.62
+	Hs
		722936 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1A_HUMAN (19-357): 1.99e-75: 242: 20.75
+	Hs
		626688 FLNC_HUMAN (32-2647): 0: 1432: 35.96		ADA1D_HUMAN (4-319): 1.75e-73: 239: 22.84
+	Hs
		521497 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		MTR1B_HUMAN (1-362): 9.76e-84: 260: 100.00
+	Hs
		656944 ACTN2_HUMAN (6-459): 1.76e-121: 410: 23.62		5HT1B_HUMAN (4-329): 4.1e-70: 225: 17.59
+	Hs
		521496 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		MTR1A_HUMAN (36-354): 2.47e-66: 215: 62.38