HitPredict

Interactor 1: FLNA (P21333)
Filamin-A (FLN-A) (Actin-binding protein 280) (ABP-280) (Alpha-filamin) (Endothelial actin-binding protein) (Filamin-1) (Non-muscle filamin)
Gene: FLNA

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	33849069, 36517590
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 2647 Hs			1 746
+	Mm
		1149776 FLNA_MOUSE (1-2647): 0: 2784: 97.32		Q6AXH7_MOUSE (1-746): 0: 832: 96.41
+	Hs
		261271 FLNB_HUMAN (28-2647): 0: 2710: 69.63		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		331721 FLNA_HUMAN (1-2647): 0: 2776: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		598279 FLNA_HUMAN (1-2647): 0: 2776: 100.00		EHMT2_HUMAN (467-732): 1.91e-68: 247: 24.21
+	Hs
		963337 SPTB2_HUMAN (22-460): 2.2e-118: 423: 24.62		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		521552 ACTN1_HUMAN (20-459): 1.14e-118: 402: 23.53		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		211587 ACTN4_HUMAN (23-382): 4.2e-112: 383: 27.01		EZH2_HUMAN (1-746): 0: 862: 100.00